Indian Journal of
Chemistry |
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Sect. B: Organic Chemistry
including Medicinal Chemistry |
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VOL. 47B |
NUMBER 9 |
September
2008 |
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CONTENTS
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Papers
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1397 |
Synthesis of
biologically active 3-(2-oxo-2H-benzopyran-6-yl)-2-(-2-oxo-2H-benzopyran-6-ylimino)-thiazolidin-4-one
and its derivatives |
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Vinata V Mulwad* & Sagar A Mayekar |
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1402 |
A mild and versatile
synthesis of bis(indolyl)methanes and tris(indolyl)alkanes catalyzed by
antimony trichloride |
Antimony
trichloride is found to be a mild and efficient catalyst for electrophilic
substitution reaction of indole derivatives with a variety of carbonyl
compounds in acetonitrile to afford the corresponding bis(indolyl)-methane in
excellent yield. a,b-Unsaturated aldehydes give tris(indolyl)alkane
under the same reaction condition. |
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Pradip Kundu & Gourhari Maiti* |
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1407 |
The reactions
of polyhalogenated-2-nitro-1,3-butadiene with alkylthio, thiomorpholine and
piperazine derivatives |
Mono(thio)substituted-1,3-nitrodiene
compounds 3a-c give 5a, 5c, 7a, 7c, 9a, 9c, 11a, 11c, 13a,
13b with thiomorpholine 4 and piperazine derivatives 6,
8, 10, 12. The new
compound 3a is synthesized from
reaction of 1 with 2a. The compound 7b crystallizes
in the monolinic crystal system (space group P21/n) with the n-butyl group attached to S1 and C2Cl3
group disordered. The butadiene unit is
not completely planar as can be expected if the two double bonds are fully
conjugated. The structure has been solved by direct
methods by using SHELXS-97 program and refined by using SHELXL-97 to the
residul index R1= 0.048. |
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Cemil Ibis* & |
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1414 |
Enantiospecific synthesis of (+)-trans-a-himachalene via an intramolecular type II carbonyl ene reaction |
Enantiospecific synthesis of (+)-trans-a-himachalene, starting from (R)-carvone, has been accomplished. |
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A
Srikrishna* & P |
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1423 |
Construction of spiro[4.5]decane via
ring-closing metathesis reaction: Formal synthesis of acorone and isoacorones |
Two
approaches for formal synthesis of spirosesquiterpenes acorones have been
described. |
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A Srikrishna* &
M Srinivasa Rao |
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Notes |
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1430 |
Titanocene(III)
chloride mediated radical-induced synthesis of 3,4-disubstituted tetrahydrofurans:
Formal synthesis of (±)-burseran and (±)-dehydrocubebin |
Sinthesis of
3,4-disubstituted tetrahydrofurans has been achieved via radical cyclization of
epoxides using titanocene(III) chloride (Cp2TiCl) as a
transition-metal radical source. The radical initiator (Cp2TiCl)
is generated in situ from
commercially available titanocene dichloride (Cp2TiCl2)
and zinc dust in THF under argon. Formal synthesis of two bioactive lignans,
burseran and dehydrocubebin has also been accomplished through the radical
technology. |
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S Jana,
M Paira & S C Roy* |
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1435 |
Synthesis of p-tert-butylcalix[8]arene ether derivatives |
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Jianmin Yi, Kewen Tang*, Saijin
Huang & |
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1438 |
Synthesis and antibacterial activity of
6-(5-phenyl-[1,3,4]thiadiazol-2-ylamino)-benzopyran-2-ones |
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Sagar A Mayekar & Vinata V Mulwad* |
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1443 |
Studies on synthesis of unsymmetrical 2,2˘-bisbenzimidazole
sulphides of pharmacological interest |
The synthesis of 2-(a-thioethyl-2˘-benzimidazolyl)- benzimidazole 3 by alternative routes is
described. |
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R=H, CH3, OCH3,
NO2, Cl |
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P K Dubey*, A
Naidu, P V V Prasada Reddy, |
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1447 |
The structure of Hantzsch coumarin |
The dimethyl dicoumarin prepared by
Hantzsch and Zurcher has been characterized as 4,6-dimethyl-2H,8H-benzo[1,2-b:4,5-b’]dipyran-2,8-dione by unambiguous synthesis of both angular and
linear pyranocoumarins by Wittig reaction promoted by clay and comparing them
with authentic Hantzch coumarin prepared as described in literature. This is
the first record of synthetic proof for the structure of Hantzch coumarin |
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P
Ramesh*, Anoop T Das, P Mohandass & R Nagasathya |
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1451 |
Synthesis and
pharmacological activities of novel furobenzopyrone and benzofuran
derivatives |
The
reactions of 2-cyanoacetohydrazide and 2'-acetyl -2-cyano-acetohydrazide with
each of furobenzopyrone derivatives 1a-d and benzofuran derivatives 10a,b
have been studied. The antimicrobial and antiinflammatory activity of
the new compounds have also been evaluated. |
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E R
El-Sawy*, Kamel H Shaker, A H Mandour, |
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1463 |
An efficient synthesis of
1,5-benzodiazepines catalysed by GaCl3 under solvent free
conditions |
Various 1,5-benzodiazepine derivatives
have been synthesized from o-phenylenediamines
and ketones using catalytic amount of GaCl3 (5 mol%) under solvent
free conditions. This method is facile, efficient, environmentally benign and
affords 1,5-benzodiazepines in excellent yield. |
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Sanjay
Kumar & Jagir S Sandhu* |
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Authors for correspondence are indicated by (*) |
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