Indian Journal of Chemistry
Sect. B: Organic Chemistry including Medicinal Chemistry Total visitors: 1,747  since 16-04-09
VOL. 48B		NUMBER 4		April 2009
CONTENTS
Papers
545	An efficient method for the synthesis of 2,3-dihydro-1H-isoindoles		The synthesis of N-substituted 2,3-dihydro-1H-isoindoles from a,a¢-dibromo-o-xylene and various primary amines in basic medium under ambient conditions is described. Especially the selection of 1,4-dioxane as solvent and sodium hydroxide as suitable base to maintain the homogeneity of the medium are key steps to promote the reaction efficiently. Primary alkyl amines react faster as compared to their aromatic analogoue under the conditions studied. Irrespective of the starting amine used all the reactions proceed smoothly and provide 2,3-dihydro-1H-isoindoles derivatives in excellent yields compared to hitherto known methods.
	R= Aliphatic (C5-C10), Alkyl aromatic, Aromatic and Benzylic
	Adimurthy Subbarayappa* & Paresh U Patoliya Analytical Science Division, Central Salt and Marine Chemicals Research Institute, (CSIR) Gijubhai Badheka Marg, Bhavnagar 364002, India
553	Synthesis and NMR spectral study of some 5-aryl-3-methylcyclohex-2-enones and 5r-aryl-3t-cyano-3c-methylcyclohexanones		Eight 5-aryl-3-methylcyclohex-2-enones and seven 5r-aryl-3t-cyano-3c-methylcyclohexanones have been synthesized. NMR spectral data of these compounds are discussed.
	S Kamatchi, R T Sabapathy Mohan, R Gomathi & K Pandiarajan* Department of Chemistry, Annamalai University, Annamalainagar 608 002, India
563	Synthesis and antibacterial activity of 1,3-diaryl-4-cyanopyrazoles		A mild, short and simple method for the small scale synthesis of pharmaceutically important 1,3-diaryl-4-cyanopyrazoles 3 is reported from acetophenone arylhydrazones 1 through a two step reaction. All the title compounds have been subjected to in vitro antibacterial testing against four pathogenic strains namely, S.aureus, B.subtilis (gram positive) and gram negative bacteria namely, P.aeruginosa and E.coli.
	Om Prakash*, Rashmi Pundeer, Pooja Ranjan, Kamaljeet Pannu , Yogita Dhingra & K R Aneja Department of Chemistry, Kurukshetra University, Kurukshetra 136 119, India
569	Synthesis of an amino moiety in Trovafloxacin by using an inexpensive amidine base, N,N-diethylacetamidine		The simple and inexpensive amidine base, N,N-diethylacetamidine, has been prepared and utilized in the construction of bicyclic hetero compound, 4 and employed for further reduction of amidic carbonyl groups of 4 by using NaBH4/I2-THF condition which is an efficient and commercially viable method to prepare 5 towards the synthesis of amino moiety 1, in Trovafloxacin 2 an antibacterial agent.
	G Madhusudhan*, V Balraju, T Rajesh, B Venkata Narayana & R Naveen Reddy Inogent Laboratories Pvt. Ltd., A GVK BIO Company, 28A, IDA, Nacharam, Hyderabad 500 076, India
574	Simple and rapid synthesis of N^α^-urethane protected β-amino alcohols and peptide alcohols employing HATU		An efficient and one-pot synthesis of N^α^-protected β-amino alcohols starting from N^α-Fmoc-/Bsmoc- /Boc-/Z-α-amino acids and peptide acids using HATU and NaBH4 has been described.
	R= CH2C6H5, CH(CH3)2 , H, CH2CH(CH3)2, CH3 moiety.
	Vommina V Sureshbabu*, N S Sudarshan & G Chennakrishnareddy Peptide Research Laboratory, Department of Studies in Chemistry, Central College Campus, Bangalore University, Dr. B. R. Ambedkar Veedhi, Bangalore 560 001, India
	Notes
580	Conformational analysis of some N-hydroxypiperidin-4-one oximes		Synthesis and conformational analysis of some N-hydroxypiperidin-4- one oximes are reported.
	G Baskar*, M Gopalakrishnan & J Winfred Jabaraj Department of Chemistry, Annamalai University, Annamalai Nagar 608 002
585	A practical, clean and green synthesis of vibrindole and bis(indolyl)methanes catalyzed by alum [KAl(SO4)2.12H2O] in water
	Sanjay Kumar, Inderpreet S Grover & Jagir S Sandhu* Department of Chemistry, Punjabi University, Patiala 147 002, India
590	N-Desmethyltriptans: One pot efficient synthesis of N-methyl-2-[5-[substituted-1H-indole-3-yl]ethanamines		A straightforward and highly improved method to synthesize N-methyl-2-[5-[substituted-1H-indole-3-yl]ethanamines 4-6, which are the metabolites of tryptans 1-3, is reported.
	Vasantha Mittapelli*, Purna Chandra Ray, Yogendra Kumar Chauhan & Debashish Datta Matrix Laboratories Limited, Plot No 34 A, Anrich Industrial Estate, Bollaram, Jinnaram (Mandal), Medak Dist 502 325, India
595	The synthesis and structure of 1-[3-{(2-hydroxybenzylidene)amino}phenyl]ethanone		Two Schiff base ligands SACPNyH and 5BrSACPNyH are synthesised from the condensation reactions of salicylaldehyde and 5-bromosalicylaldehyde respectively with 3-aminoacetophenone and characterized by elemental analyses, mass, electronic and infrared spectral studies. The molecular structure of SACPNyH determined by single crystal X-ray crystallographic study is discussed.
	Rajib Lal De*, Jaydeep Mukherjee, Mahuya Mandal, Lovely Roy, Ruchika Bhowal & Indrajit Banerjee Department of Chemistry, Jadavpur University, Kolkata 700 032, India
599	Mild and efficient synthesis of 1,2,4-triazolo[4,3-a][1,8] naphthyridines using FeCl3 in the solid state		An efficient and mild procedure for the synthesis of 1,2,4-triazolo[4,3-a][1,8]naphthyridines 4 using FeCl3.6H2O in the solid state at room temperature is described.
	K Mogilaiah*, K Vidya & T Kumara Swamy Department of Chemistry, Kakatiya University, Warangal 506 009, India
602	A facile and efficient microwave-mediated S-alkylation of thiophosphates		A simple and rapid microwave assisted S-alkylation of O, O’-diethyl thiophosphate has been described.
	Lokesh Kumar Pandey, Avik Mazumder & Uma Pathak* Synthetic Chemistry Division, Defence Research & Development Establishment, Gwalior 474 002, India
606	An efficient synthesis of novel 2-amino-4-aryl-6-ferrocenyl pyrimidines		A series of 2-amino-4-aryl-6-ferrocenyl pyrimidines have been synthesized using cyclocondensation of 3-aryl-1-ferrocenyl-2-propen-1-ones with guanidine hydrochloride in basic medium. All newly synthesized compounds have been fully characterized by elemental analysis, IR, ^1H NMR and mass spectral data. The antibacterial activity of all the compounds against Staphylococcus aureus and Escheria coli has been evaluated.
	G S Rashinkar, S B Pore, K B Mote & R S Salunkhe* Department of Chemistry, Shivaji University, Kolhapur 416004, India
611	A simple and efficient PTT-mediated synthesis of a-azidoketones in [bmim][BF4] ionic liquid		A simple and efficient one-pot method has been described for the direct synthesis of a-azidoketones from various ketones possessing a-hydrogen by reaction with phenyltrimethylammonium tribromide (PTT) and subsequent treatment with NaN3 in ionic liquid. The procedure gives high yield and the ionic liquid can be reused.
	Anil Kumar*, Israr Ahmed, M Sudershan Rao, Gautam Patel & Dalip Kumar Chemistry Group, Birla Institute of Technology and Science, Pilani 333 031, India
	Authors for correspondence are indicated by (*)