Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry;

Total visitors:9177 since 12-10-2010

VOL. 49B


October 2010







Total synthesis of enokipodins A-D and cuparene-1,4-diol


Details of the first total synthesis of enokipodins A and B, and formal total synthesis of enokipodins C and D, cuparene-1,4-diol and cuparene-1,4-dione have been described.






A Srikrishna* & M Srinivasa Rao


Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, India









Simple and efficient synthesis of Fmoc/Boc/Cbz-protected-b-amino alcohols and peptidyl alcohols employing Boc2O


A facile method for the synthesis b-amino alcohols using sodium borohydride is demonstrated. Further, the protocol is also extended for the conversion of N-urethane protected peptide acids to their corresponding alcohols.




Pg : Fmoc, Boc, Cbz

R: CH3, CH2C6H5 , CH(CH3)2, CH2CH(CH3)2, CH2COOtBu,

CH2CH2COOtBu, CH2C6H4 OtBu, CH2OBzl, (CH2)4NHCbz,





Lalithamba H S & Vommina V Sureshbabu*


Peptide Research Laboratory, Department of Studies in Chemistry, Central College Campus, Bangalore University,
Dr. B. R. Ambedkar Veedhi, Bangalore 560 001, India















Michael adduct: Synthons for a new class of heterocycles


The Michael adduct, ethyl 3,4-diarylsulfonyl-2-cyanobutyrate has been used as synthon to develop amino-pyrazolones, amino-isoxazolones, amino-hydroxypyrimidinones, amino-mercaptopyrimidinones and imino-pyrimidinediones.












A Padmaja*, T Payani, A Muralikrishna & V Padmavathi


Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, India

















Antibacterial and antitubercular activities of some diphenyl hydrazones and semicarbazones


A series of diphenyl hydrazones and semicarbazones have been synthesized and their antibacterial and antituberculosis properties are reported.












A S Raja*, A K Agarwal, N Mahajan, S N Pandeya & S Ananthan


1Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi 221 005, India















Synthesis and characterisation of novel starburst phase transfer catalyst


Phase transfer catalyst, 3,5-bis[(2-methyl-naphthylene-1-yl)­phe­nyl­amino-phenyl]-butyl-(2-methoxy-naphthalene-1-yl)­phe­nyl­ammonium­bromide (BPBPB) has been synthesized. The application studies of BPBPB as a Phase Transfer Catalyst (PTC) is studied by utilizing common organic reactions. BPBPB is an efficient catalyst for certain organic reactions and it is regenerative to about 95% in weight.











Siji Mathew, Divia N, T D Radhakrishnan Nair & Karickal R Haridas*


School of Chemical Sciences, Kannur University, Payyanur Campus, Edat P.O. 670 327, India









A facile multicomponent synthesis of tetra­substituted imidazoles using Fe3+-K10 catalyst under solvent-free microwave conditions


An efficient, microwave assisted, multi-component synthesis of 1,2,4,5-tetrasubstituted imidazoles has been described.










D S Raghuvanshi & Krishna Nand Singh*


Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi 221 005, India















Synthesis and antiparkinsonian activity of some new adamantyl thiazolidinonyl/azeti­dinonyl in­dole derivatives


Synthesis and antiparkinsonian activity of new adamantyl thiazolidinonyl/azetidinonylindole derivatives are reported herein. The compound 4a exhibits the most potent anti­parkinsonian activity.






Sunil Kumar, Hemlata Kaur, K K Saxena, Monica Sharma, Pinki Vishwakarma & Ashok Kumar*


Medicinal Chemistry Division, Department of Pharmacology, L.L.R.M. Medical College, Meerut 250 004, India









Synthesis and in-vitro biological evaluation of some quinazolin substituted pyrazoles, pyrazol­ones and 1,3,4-oxadiazoles


In the present study, a new series of pyrazoles 6a,b, pyra­zolones 7a,b and 1,3,4-oxadiazoles 8-10a,b having the quina­zolinone ring in the molecular framework have been synthe­sized from hydrazides 5a,b, possessing potent antibacterial and insecticidal activities.






Pramilla Sah* & Vasudha Kaul


Department of Chemistry, J.N.V. University, Jodhpur 342 005, India















A one-pot synthesis of isoxazolyl benzo[b] [1,4] oxazin-3(4H)-ones via Smiles rearrangement


A one-pot synthesis of isoxazolyl benzo[b] [1,4]oxazin-3(4H)-ones has been achieved by interaction of 2-chloro­phenols, chloroacetyl chloride and different isoxazole amines involving Smiles rearrangement from readily available starting materials.





E Rajanarendar*, M Nagi Reddy & K Rama Murthy


Department of Chemistry, Kakatiya University, Warangal 506 009, India









Microwave-assisted synthesis and antibacterial activity of 1-[3-(3-fluorophenyl) [1,8]naphthyridn-2-yl]-3-(2-oxo-2H-chromenyl)-1H-4-pyrazole­carb­aldehydes using solid support


A simple and efficient method for the syn­­the­­sis of 1-[3-(3-fluorophenyl)[1,8]naphthyridn-2-yl]-3-(2-oxo-2H-chromenyl)-1H-4-pyrazolecarbaldehydes 4 in the presence of DMF-POCl3 (Vilsmeier-Haack reagent) using silica gel as solid support under microwave irradiation is described. The compounds 4 have been screened for their antibacterial activity.





K Mogilaiah*, R Shiva Prasad & K Shiva Kumar


Department of Chemistry, Kakatiya University, Warangal 506 009, India









An elegant one-pot synthesis of isoxazolo[2,3-a]pyrimidines


An elegant one-pot synthesis of isoxazolo [2,3-a]pyrimidines has been achieved by reaction of 3-amino-5-methylisoxazole with 4-arylidene-2-phenyl-5-oxazolones. Treatment of 3-amino-5-methylisoxazole with chalcones also resulted in the formation of isoxazolo [2,3-a]pyrimidines in a single step.The structure of the products have been elucidated by spectral and analytical data.





E Rajanarendar*, S Raju, M Nagi Reddy & K Rama Murthy


Department of Chemistry, Kakatiya University, Warangal 506 009, India















Sodium carbonate: A versatile catalyst for Knoevenagel condensation


Catalytic amounts of sodium carbonate (Na2CO3) catalyze the condensation of aromatic aldehydes with active methylene compounds to afford arylmethylidene products under the grindstone method. The reactions go to completion within 1–5 min. at 26ºC and give products in excellent yields.





M A Pasha*, Krishnappa Manjula & V P Jayashankara


Department of Studies in Chemistry, Central College Campus, Bangalore University, Bangalore 560 001, India






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