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Indian Journal of Chemistry

  Sect. B: Organic Chemistry including Medicinal Chemistry














Synthesis of methyl 3-deoxy-a/b-d-ribo­fu­rano­side by regioselective reductive opening of methyl 2,3-anhydro-a/b-d-ribofuranoside

The title synthesis is described.
  Hari Babu Mereyala* & Rajashekar Bantu  

Synthesis and semiempirical calculations of imidazolidine, isoxazolone and thiazoline thiol derivatives of acenaphthylene-1,2-dione

A convenient synthesis of acenaphthylidene derivatives involving Knovenaegel type condensation of imidazolidine, oxazolidine and thiazolidine derivatives with acenaphthylene-1,2-dione has been described. The structures of newly synthesized products have been established by spectral technique. Exclusive formation of anti-monocondensation products has been explained on the basis of semiempirical calculations.



R T Pardasani*, P Pardasani, I Sharma, A Saxena & S Kohli

3081 Study of [1,3]sigmatropic hydrogen migra­tion in cytosine and cytidine by AM1 method The geometry and electronic structure of cytosine and cytidine involving [1,3]sigmatropic hydrogen migration in the formation of tautomers have been fully optimized and calculated by semiempirical molecular orbital AM1 method.

Bojja Rajeshwar Rao

Theoretical perspectives on the Cope rear­range­ment in bullvalene systems

Using the semi-empirical AM1 SCF-MO method, transition states have been located for Cope rearrangements in various bullvalene systems, including degenerate unsubstituted and difluoro substituted cases as well as non-degenerate monofluoro substituted cases.


Pebam Munindro Singh & R H Duncan Lyngdoh*
3102 Studies on quinazolines: Part II–Synthesis and anti­micro­bial evaluation of some 2,2-disubstituted-3,3-biquinazolin-4(3H)-ones N-(2-Styryl-, 2-p-chlorostyryl- or 2-p-nitro-styryl-4-oxo-3H-quinazolin-3-yl)-2-aminobenzamides 6a-c react with triethyl orthoesters to furnish some new 2-styryl-, 2-p-chlorostyryl- or 2-p-nitrostyryl-2-substituted-3,3-biquina­zolin-4(3H)-ones 7a-c–9a-c. An alternative synthesis of (7-9)b has been accomplished by reaction of acetyl­anthranil with 2-amino-2-styryl, 2-p-chlorostyryl- or 2-p-nitrostyryl-quinazolin-4(3H)- ones 4a-c. The synthesised products have been tested for antimicrobial activities using methaqualone as reference standard.


A A F Wasfy



Chemoselective reaction of bisheterocycle dicarboxylate towards hydrazine hydrate : Synthesis and antimicrobial activity of some new trisheterocycles : 5-Pyrrolylaminocarbonyl/oxadiazolyl/mercaptooxadiazolylmethoxy-1-furfuryl-2-methylindoles

  Guru S Gadaginamath* &
Dundappa S Donawad
3113 Synthesis and antibacterial properties of nitrofuryltriazolothiadiazepines

Synthesis, characterization and antibacterial screening of nitrofuryl triazolothiadiazepines have been described.


B Shivarama Holla*, K Shridhara &

M K Shivananda

3117 Chemical examination of the mangrove plant Avicennia officinalis

A naphthofuran, (-)avicennol C (1)  has been isolated from Avicennia officinalis besides known triterpenoids and steroids.




  A S R Anjaneyulu*, Y L N Murthy,
V Lakshman Rao & K Sreedhar


Lanthanide complexes in organic synthesis: Synthesis of ethers from allyl alcohols

The hepta coordinated Ln(III) complexes with N,N¢-ethylene-bis-(2-aminobenzamide) [EBAB] and N,N¢-pro­pylene-bis-(2-aminobenzamide) [PBAB], [Ln(EBAB)Cl3] or [Ln(PBAB)Cl3], catalyze the ether formation reactions from allyl alcohols and different nucleophiles. The overall yields of the products are found to be 70–83%.



S J Swamy*, D Nagaraju & K Suresh









A facile one- pot synthesis of 7-substituted-5-methoxycarbonyl-1H-2, 3-dihydro-1, 4-ben­zo­diazepin-2-ones from 5-substituted-N-chlo­ro­acetyl isatins

7-Substituted-5-methoxycarbonyl-1H-2,3-dihydro-1,4-benzodiazepin-2-ones 3a-c have been prepared in one-pot from 5-substituted N- chloroacetyl isatins 2a-c.


2a, R=Me                                     3a, R=Me

2b, R=OMe                                  3b, R=OMe

2c, R=NO2                                   3c, R=NO3


Anjul Singh, Reenu Sirohi, Sudha Shastri & D Kishore*









Solid phase synthesis of benzimidazole ketones and benzimidazole chalcones under solvent-free conditions

Oxidation of 1-alkyl/aralkyl-2-(a-hydroxyalkyl/aryl)­ben­zi­­midazoles 1 yields 1-alkyl/aralkyl-2-acylbenzi­mid­azoles 2. The compound 2a (R2=CH3) on condensation with aromatic aldehydes yields the corresponding chalcones 3 under solvent-free conditions.


1                                                                                                2


 2a                                                                                             3


P K Dubey*, C Ravi Kumar & Balaji Babu










Synthesis of 4, 5-dihydro-3-(1'-naphthyl)-2H-pyrazolino[3, 4-a]carbazoles and 3-(1'-naph­thyl)isooxazolo[3,4 -a]carbazoles




Vandana T & K J Rajendra Prasad*









Synthesis of the steroidal pyrazolines


Synthesis of steroidal pyrazolines  (4 and 5) from cholest-4-en-3-one 1, 3b-acetoxycholest-5-en-7-one 2 and 3b-chlorocholest-5-en-7-one 3 using hydrazine hydrate in glacial acetic acid has been reported.



Shamsuzzaman* & Nazish Siddiqui









Preparation of unsymmetrical sulfides using modified zeolite catalysts

Reaction between benzyl chlorides and thiols is catalysed efficiently by novel modified mildly basic zeolites, prepared by introducing 3-aminopropyltriethoxysilane and tetra(ethylene-glycol)dimethyl ether into the cages of NaY zeolites and high yields of the corresponding sulfides are obtained.





T Esakkidurai, S Vijaikumar, D Madhavan & K Pitchumani*










Microwave assisted one pot synthesis of 9-aryl-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexa­hy­dro-1,8(2H,5H)acridinedione

Three component one step cyclocondensation to 9-aryl-3, 3, 6, 6-tetra­methyl-3, 4, 6, 7, 9, 10-hexahydro-1, 8(2H, 5H)­acri­­­dine­­dione 3 starting from readily available dimedone 1, substituted benzaldehydes 2 and ammonium acetate under microwave irradiation is reported.





S Nandagopal, G Annie & P T Perumal*









Reactions of Vilsmeier Haack reagent with aromatic and heterocyclic aldoximes

Reactions of Vilsmeier Haack reagent with various aromatic and heterocyclic aldoximes give amides. Nitriles are shown to be the intermediates in this reaction. Vilsmeier Haack reaction with amides in turn furnishes nitriles.




Radhika Kusurkar*, Shailesh Goswami & Sandhya Vyas









Synthesis and antibacterial activity of N-2-(hydroxypropyl)/N-proteo b-lactams

Synthesis and antibacterial activity of some new N-(2-hydroxypropyl)-b-lactams has been described along with two step oxidation to N-proteo b-lactam.





S D Sharma*, Susmita Bhaduri & Seema Kanwar










New biologically active limonoids and flavonoids from Aphanamixis polystachya

Evidence is presented for the isolation and structures of three new compounds: Amoorinin-3-O-α-l-rhamno­pyra­no­syl-(1®6)-β-d-gluco­pyranoside 1, 8-methyl-7,2¢,4¢- tri­me­thyl­flavanone-5-O-α-l-rhamnopyranosyl-(1®4)-β-d-gluco­­pyranosyl-(1®6)-β-d-glucopyranoside 2 and 8-methyl-5,7,3¢,4¢- tetrahydroxyflavone-3-O-α-l- arabino­pyranoside 3 which occurs together with known substances aphanamixinin from the roots of Aphanamixin polystachya. Biological screening of the compounds show antifeedant and antifungal activities.



1                                                                                      2



S K Srivastava*, S D Srivastava* &
Soumya Srivastava









Phytochemicals from Andrographis paniculata

The 5,4΄-dihydroxy-6,7-dimethoxyflavone-8-C-α-l-rham­no­side, a new flavone glycoside,three first time reported and seven known compounds have been isolated and characterized from aerial parts of A. paniculata.




Sudhanshu Saxena & D C Jain*



Farinosyn, a novel insect growth regulator from the silver fern Cheilanthes farinosa Kaulf

Insect growth regulatory bioassay guided isolation yields farinosyn 1 from the MeOH extract of silver fern Cheilanthes farinosa  Kaulf.


S Sivakumar, N A Shakil, C Devakumar* & B Subrahmanyam


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