Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry

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Rapid Communications





A new protocol for synthesis of a,b-unsaturated ketones using zirconium tetrachloride under microwave irradiation


IPC: Int.Cl.7 C 07 C






Utpal Bora, Anil Saikia & Romesh C Boruah*











A study on the reactivity of 1,3-dimethyl-2,6-diphenyl-4-piperidone : Synthesis of some novel heterocycles


IPC: Int.Cl.7 C 07 D

Some interesting heterocycles, viz.: tetrahydro­pyridine, diazepanone, oxazepanone, pyridoindole, thiazolopyridine, furanylmethylenepiperidone, pyrido­pyrimidone and pyridopyrimidinethione are prepared from piperidin-4-one by exploiting ketomethylene functionality using microwave, ultrasound and conventional methods.




V Padmavathi*, T V Ramana Reddy,

K Audisesha Reddy, A Padmaja &

D Bhaskar Reddy









Synthesis and anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation activities of 3,5-dimethyl pyrazoles, 3-methyl pyrazol-5-ones and 3,5-disubstituted pyrazolines


IPC: Int.Cl.7 C 07 D

Pyrazole derivatives of diclofenac, ibuprofen, flurbiprofen and 2,4-dichlorophenoxy acetic acid have been synthesized with the aim of reducing their ulcerogenic activity. Moreover, pyrazoline derivatives of ibuprofen have also been synthesized.



Mohd Amir* & Shikha Kumar















Beibersteneolide-a and -b: Two new sesquiterpene lactones from Achillea beiberstenii


IPC: Int.Cl.7 C 07 D

Two new sesquiterpene lactones obtained from Achillea beiberstenii have been characterized as 3a, 9b- diacetoxy- 1b, 10-epoxy 5(4)-en-germacran -6b, 12-olide, named as beibersteneolide-a 1, and 4, 9b-dihydroxy-2(1), 6(5), 11(13) triene-guaian–7a, 12-olide, designated as beibersteneolide-b 2.








Tawfeq A Al-Howiriny , Jaber S Mossa &

Bahar Ahmed*









Condensation of reactive phenols with aromatic 1,2-diketones: A single step protocol for synthesis of benzo-fused g-lactones


IPC: Int.Cl.7 C 07 C

Condensation of certain reactive phenols with 1,2-diketones under acid/Lewis acid catalysis affords benzofused g-lactones in reasonable yields.







Sabir H Mashraqui*, Mamta B Patil, Hitesh D Mistry, Mohamed Ashraf & Subramanian Sundaram









Synthesis and characterization of di(p-fluoro­benzyl)tin bis(heteroaromatic carboxylate) and crystal structure of di(p-fluorobenzyl)tin bis(3-pyridinecarboxylate)


IPC: Int.Cl.7 C 07 D

Reaction of di(p-fluorobenzyl)tin oxide with heteroaromatic carboxylic acid in 1:2 stoichiometry yields compounds of the type (4-F-Bz)3Sn(OOCR)2 [R=3-pyridinyl 1, 4-pyridinyl 2, 2-pyridinyl 3, 2-indolyl 4, 2-furanyl 5, 2-thiophenyl 6, 3-indolyl 7, 3-indolmethyl 8]. These compounds have been characterized by elemental analysis, IR, 1H and 119Sn NMR spectra. The crystal and molecular structure of compound 1 has been determined by X-ray single crystal diffraction.





Han DongYin*, Qi Bao Wang & Sheng Cai Xue















Polymer-bound cationic Rh(I) phosphine catalyst for homogeneous asymmetric hydrogenation


IPC: Int.Cl.7 C 07 D

Facile synthesis of polymer bound Rh(I) phosphine catalyst for homogeneous asymmetric hydrogenation is described.  Polymer bound Pyrphos Rh(I) complex catalyses hydrogenation of prochiral Z-a-acetamido cinnamic acid to S-N-acetyl phenyl alanine with 76% ee.  The polymer bound catalyst is cleanly separated from the product by membrane osmodialysis. 



Nirmal Koshti*, Shubhangi Naik & Bharat Parab









Improved synthesis of an energetic material, 1,3,3-trinitroazetidine (TNAZ) exploiting 2-iodoxy benzoic acid (IBX) as an oxidising agent


IPC: Int.Cl.7 C 07 D

The synthesis and characterisation of a powerful strained ring energetic compound which is of considerable interest to military agency, has been discussed. Most of the effort for producing the next generation of energetic materials is currently centered around the production of TNAZ. The advent of this new high energy explosive presents the possibility of increased performance with reduced sensitivity.



Alok Singh, Nirmala Sikder & Arun K Sikder*









Single crystal XRD structural elucidation of
1-oxopyridinium-2-thioacetic acid


IPC: Int.Cl.7 C 07 D




Sudalaiandi Kumaresan*, Palani Ramadevi, Balasingh Ravindran Durainayagam & Rosa Walsh














Michael addition of active methylene compounds to a,b–unsaturated sulfones


IPC: Int.Cl.7 C 07 D

The Michael addition of dimethyl malonate and ethyl cyanoacetate to a,b-unsaturated sulfones in the presence of Triton-B and K2CO3 is studied.





V Padmavathi*, D R C Venkata Subbaiah,

A Balaiah, B Chandra Obula Reddy & A Padmaja









Synthesis of isoflavones containing naturally occurring substitution pattern by oxidative rearrangement of respective flavanones using thallium(III) p-tosylate


IPC: Int.Cl.7 C 07 D






Om V Singh*, M Muthukrishnan &

M Sunderavadivelu









Design, synthesis and characterisation of a novel anticancer prodrug having antiproliferative activity against prostrate tumour


IPC: Int.Cl.7 C 07 C

5'-O-Curcuminyl-diglycinoyl-DNA had antipro­li­fera­tive activity against prostrate tumor derived DU145 cells. It acts by hybridisation with target telomerase sequence.







Satyendra Mishra, Snehlata Tripathi, Roli Mishra & Krishna Misra*















Rapid and convenient synthetic strategy for
2-amino-4-aryl-5-aryl-sulfonyl thiazoles


IPC: Int.Cl.7 C 07 D

A convenient one pot synthetic strategy for 2-amino-4-aryl-5-aryl sulfonyl thiazoles has been first time introduced.







V E Bhingolikar, S R Mahalle, S P Bondge &

R A Mane*











Synthesis and biological screening of some new novel indole derivatives


IPC: Int.Cl.7 C 07 D

Synthesis of some novel indole derivatives has been undertaken by the reaction of 1,4-benzoquinone with ethyl-b-(arylamino)-crotonates in the presence of nitrogen atmosphere or in the absence of nitrogen atmosphere.







D S Mehta, K H Sikotra & V H Shah*









Base induced carbon-nitrogen (C=N) double bond migration in Schiff bases


IPC: Int.Cl.7 C 07 C

Various Schiff bases are prepared to study base induced carbon-nitrogen double bond migrations. Schiff bases derived from aliphatic aldehydes display highest selectivity. Hydrolysis of the resulting rearranged Schiff base provides an entry to make amines from aldehydes.









B Gangadasu, P Narender, B China Raju* &

V Jayathirtha Rao


















Reaction of 2'-hydroxy-5'-acetamido chalcones with dimethyl sulfoxide-iodine, pyridine-mercuric (II) acetate and triethanolamine


IPC: Int.Cl.7 C 07 D

Reaction of 2'-hydroxy-5'-acetamido chalcones with catalytic amount of iodine in DMSO affords flavone, molar amount of mercuric acetate in pyridine gives aurones while with phenylhydrazine and hydrazine hydrate gives pyrazoline in triethanolamine medium.



Nitin N Agrawal* & P A Soni









Two dimeric flavonoids from Bauhinia purpurea


IPC: Int.Cl.7 C 07 D

Bauhinia purpurea leaves yield two new dimeric flavonoids namely, bis [3¢,4¢-dihydroxy-6-methoxy-7,8-furano-5¢,6¢-monomethylallyloxy]-5-C-5-biflavonyl 1 and (4¢-hydroxy-7-methyl-3-C-a-l-rhamnopyrano­syl)-5-C-5-(4¢-hydroxy-7-methyl-3-C-a-glucopyrano­syl) biflavonoid 2 with protein precipitating capacity 214.4 and 199.24 mgBSA/g, respectively.





SurabhiYadav & Brijesh K Bhadoria*















A facile synthesis of 1-hydroxy-5-chloro-benzo­[f]­[2,7]naphthyridines



IPC: Int.Cl.7 C 07 D

Synthesis of the titled compounds from 2-chloro-3-formyl quinolines is reported.













N Sampathkumar, S Thiruvaranga Ramalingam & S P Rajendran*









Wolff rearrangement of Nα- Boc-/Z-protected aminodiazoketones to the corresponding β-amino acids under microwave irradiation



IPC: Int.Cl.7 C 07 C

The  Wolff  rearrangement  of  Na-Boc-/Z-protected    aminodiazoketones assisted by microwave irradiation is described. All the resulting b-amino acids have been isolated in good yield and purity.










X= Boc-/Z- group








Kantharaju, Basanagoud S Patil & Vommina V Suresh Babu*















Synthesis and antimicrobial activity of some 3-alkyl-


IPC: Int.Cl.7 C 07 D

Eight new ethyl Nı-(3-methyl-4-arylmethyleneamino-4,5-dihydro-1H-1,2,4-triazolyl-5-one)acetates 2 and Nı - (3-methyl-4-arylmethyleneamino-4, 5-dihydro-1H-1,2,4-tria­zolyl-5-one)acetylhydrazines 3 have been synthesized. The compounds show some antimicrobial activities.



Bahittin Kahveci*, Olcay Bekircan &

Şengül Alpay Karaoğlu









Second International Symposium On Green/ Sustainable Chemistry






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Authors for correspondence are indicated by (*)

IPC: International Patent Classification

Int. Cl7.: International Classification, 7th Edition, 1999