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Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry
















Synthesis and structural study of 3-anisyl-4-(4'-pyridyl(pyridinium)thieno[2,3-b]thienophenes


IPC: Int.Cl.7 C 07 D 333/00

The synthesis of novel donor-acceptor thienothio­phenes is described to probe the presence of charge transfer interaction.



Sabir H Mashraqui*, Harini Hariharasubrahmanian,

Mohamed Ashraf & Yogesh Sangvikar








Design, development and synthesis of a novel labeled PNA monomer incorporated in DNA-hexamer to act as a hybridization probe by FRET


IPC: Int.Cl.7 C 07 K

A novel PNA monomer with adenine nucleobase and a modified backbone with charged  and a methylene substituted for  in the linker arm has been synthesized.



Vibha Shukla, Satyendra Mishra, Geeta Watal & Krishna Misra*









Synthesis of tetrasaccharide related to the repeating unit of the O-antigen from Shigella boydii type 5 in the form of its tert-butyl ester and 2-(trimethylsilyl)ethyl glycoside


IPC: Int.Cl.7 C 07 H 3/06

Starting from d-mannose, d-glucose and l-rhamnose a tetrasaccharide derivative I related to the repeating unit of Shigella boydii type 5 has been synthesized.



Samarpita Roy, Sujit Kumar Sarkar,

Balaram Mukhopadhyay & Nirmolendu Roy*














Synthesis of (R)-4,6-O-pyruvated trisaccharide related to the repeating unit of  the antigen from Shigella dysenteriae type 9 in the form of
its 2-(trimethylsilyl)ethyl glycoside


IPC: Int.Cl.7 C 07 H 3/06

Starting from d-galactose, and d-mannose a deb­locked trisaccharide, 2-(trimethylsilyl)ethyl 4,6-O-[(R)-1-methoxycarbonylethylidene]-b-d-galacto­py­r­a­n­­­­o­­syl-(1®4)-b-d-mannopyranosyl-(1®4)-b-d-galact­o­­pyranoside has been synthesized, which is a part of the repeating unit of the O-antigen from Shigella dysenteriae type 9.







Samarpita Roy, Sujit Kumar Sarkar

& Nirmolendu Roy*









A mild and efficient procedure for the preparation of dimethyl and diallyl acetals of aromatic aldehydes mediated by cerium(IV) ammonium nitrate


IPC: Int.Cl.7 C 07 C 47/27

The reaction of aromatic aldehydes with cerium(IV) ammonium nitrate in alcohols to afford the corresponding acetals is described.



i) CAN, ROH, Na2CO3, Reflux, 45 min.

R = Methyl, Allyl




Vijay Nair*, Roshini Rajan, Lakshmi Balagopal, Latha G Nair, Sindu Ros & Kishor Mohanan









Selective and clean oxidation of alcohols with benzimidazolium fluorochromate (BIFC) under solvent free conditions


IPC: Int.Cl.7 C 07 D 233/54

Benzimidazolium fluorochromate (BIFC) is an efficient and selective oxidant for alcohols under solvent free conditions. This oxidation process is effective, economical and eco-friendly.







V Sivamurugan, G Abraham Rajkumar, Banumathi Arabindoo & V Murugesan*














Reduction of aldehydes and oximes to their corresponding alcohols and amines by catalytic hydrogenation method


IPC: Int.Cl.7 C 07 D 233/54

The reduction of aldehydes such as 2-butyl-5-chloro-3H-imidazole-5-carbaldehyde and veratraldehyde, which are pharmaceutical key intermediates, have been reduced to alcohols by catalytic hydrogenation method in the presence of magnesium and also oximes are reduced to primary amines successively by magnesium/ammonium formate system, is a large scale feasible and cheaper method. The crystal structure of the product, (2-butyl-5-chloro-3H-imidazole-4-yl)methanol 1 is reported.



Basappa, B H Doreswamy, M Mahendra,

K Mantelingu, M A Sridhara,

J Shashidhara Prasad & K S Rangappa*









Synthesis and QSAR of O,O-diaryl O-ethyl phosphorothionates for their fungicidal activity against Rhizoctonia solani and Sclerotium rolfsii


IPC: Int.Cl.7 A 61K 35/00 // A 61 P 31/10

A series of O,O-diaryl O-ethyl phosphorothionates has been synthesized, their fungitoxicity against   R. solani and S. rolfsii and quantitative structure activity relationship studied.



Bijul  Lakshman A & R L Gupta*









Synthesis, characterization and biological activity of 1,3,4-substituted 2-azetidinones


IPC: INT.CL.7 C 07 C 59/54 // A61 P 31/12




V K Pandey*, V D Gupta, Mrinalini Upadhyay, Mridula Upadhyay, V K Singh &
Meenal Tandon








Synthesis and fungicidal activity of some 6-aryl-2-(-β-d-glucopyranosyl)-3-oxo-2,3-dihydro-1,3,4-oxadiazolo [3,2-b]-1,2,4,6-thiatriazine-1,1-dioxides


IPC: Int.Cl.7 C 07 D 285/00

6-Aryl-2-(β-d-glucopyranosyl)-3-oxo-2, 3-dihydro-1, 3, 4-oxadiazolo[3, 2-b]-1, 2, 4, 6-thiatriazine-1, 1-dioxides 4 have been conveniently prepared from 6-aryl-3-oxo-2, 3-dihydro-1, 3, 4-oxadiazolo[3, 2-b]-1, 2, 4, 6-thiatriazine-1, 1-dioxides 2 by reaction of β-d-1, 2, 3, 4, 6-penta-O-acetylglucopyranose and iodine.




R K Khare*, Alok Kumar Srivastava & H Singh










Synthesis of N-[2-benzyloxy-5-(2-oxiranyl)­phe­nyl]­formamide: Formal synthesis of formoterol


IPC: Int.Cl.7 C 07 C 13/20

Synthesis of N-[2-benzyloxy-5-(2-oxiranyl)phenyl]­formamide 4 from 4-hydroxyacetophenone is described to achieve the formal synthesis of formoterol 1.



Hari Babu Mereyala* & Kalyani Sambaru









Synthesis of diastereomerically pure acetals of


IPC: Int.Cl.7 C 07 H 3/02

Title synthesis is described.



Hari Babu Mereyala*, Pathuri Gopal &

Sreeman Kumar Mamidyala









Synthesis of spiroisoxazoline[5.9¢]anthrone


IPC: Int.Cl.7 C 07 C 15/28

Synthesis of novel spiroisoxazolines via 1,3-dipolar cycloaddition is described.



S Manikandan, S Karthikeyan &

R Raghunathan*










Synthesis of new bis-heteroaryl thiohydrazonates and their in situ rearrangement


IPC: Int.Cl.7 C 07 D 249/08

Synthesis of the bis-thiohydrazides 4, via  in situ rearrangement of the bis- thiohydrazonate esters 3 is reported.



Mosselhi A N  Mosselhi, Magda A Abdallah, Sayed M Riyadh & Ahmad S Shawali*









Synthesis of 1,3-diaryl-4-cyanopyrazoles from the corresponding aldoximes using dimethyl­formamide - thionylchloride complex


IPC: Int.Cl.7 C 07 D 231/02

A mild and convenient method for the synthesis of 1,3-diaryl-4-cyanopyrazoles 4 from the corresponding aldoximes 2 using dimethylformamide-thionyl­chloride complex 3 is reported.



G Jagath Reddy*, S Sailaja, K Pallavi &

K Srinivasa Rao









Synthesis of a-bromoalkanones using urea-hydrogen peroxide complex and sodium bromide over silica gel-acetic acid


IPC: Int.Cl.7 C 07

a-Bromoalkanones 2 have been synthesized by the reaction of alkanones 1 with UHP-NaBr over SiO2-acetic acid in solvent-free conditions under micro­wave irradiation.



Satya Paul, Puja Nanda & Rajive Gupta*









Synthesis of arylketones using Envirocat EPZG catalyst


IPC: Int.Cl.7 C 07 C 49/225

A safe and cost effective approach for the synthesis of arylketones by using novel and Envirocat EPZG is reported.



Sonali Ghatpande & Supriya Mahajan*










Microwave thermolysis: Part IX ¾ A rapid reduction of sulphoxides with NaH2PO2 in dry media


IPC: Int.Cl.7 C 07 C 11/06, C07 D






H M Meshram*, Y S S Ganesh, K Ramesh Babu, B Eeshwaraiah & J S Yadav









Solvent-free synthesis of 2′,3′,5′-tri-O-acetyl -2,6-dichloropurine nucleoside catalyzed by p-toluene­­­sulfonic acid using microwave


IPC: Int.Cl.7 C 07

Starting from tetraacetylribofuranose 1 and 2,6-dichloropurine 2, in the presence of p-toluenesulfonic acid, 2',3',5'-tri-O-acetyl-2,6-dichloropurine nucleo­side 3 has been synthesized in microwave oven for the first time. On comparing with the conventional methods, this method has advantages such as shorter reaction time (4.5min), better yield (83.5%), simple workup and environmental acceptability.



Text Box: 3


Text Box: 1




Guirong Qu* & Qibin Liu









Amberlyst-15 catalyzed acetylation of hetero­aromatics with acetic anhydride under solvent free conditions


IPC: Int.Cl.7 C 07 D 209/04





Biswanath Das*, Rammohan Pal,

Joydeep Banerjee, G Mahender, Harish Holla &

K Venkateswarlu














A mild and efficient method for the acetylation of alcohols


IPC: Int.Cl.7 C 07 C 39/00

The acetylation of alcohols has been carried  out efficiently in the presence of a catalytic  amount of Zr(HSO4)4. All reactions are  performed at room temperature and under  heterogeneous conditions  in good to high  yields.



F Shirini*, M A Zolfigol & A Safari









Synthesis of 2-aryl-7-(3-oxo-2H-[1,4]-benzoxazin-6-yl)pyrazolo[1,5-a]pyrimidines as potential COX-2 inhibitors


IPC: Int.Cl.7 C 07

A series of 2-aryl-7-(3-oxo-2H-[1,4]-benzoxazin-6-yl)pyrazolo[1,5-a]pyrimidines (8a-d and 9a-d) have been synthesized and evaluated for COX-2 inhibitor activity.



G Jagath Reddy*, S Sailaja & K Srinivasa Rao, P Reddanna & D Bharat Reddy









A convenient synthesis of Nabumetone ¾ An anti-inflammatory drug candidate


IPC: Int.Cl.7 C 07 C 15/24

A facile and industrially viable approach to Nabumetone, an anti-inflammatory agent, is reported.



G Srinivasulu, A Raghupathi Reddy,

Ch Nagaraju, P Pratap Reddy &

M Satyanarayana Reddy*









Chemical examination of the mangrove plant Dalbergia spinosa Roxb


IPC: Int.Cl.7 C 07

A new neoflavonoid 1 has been isolated from Dalbergia spinosa Roxb besides known triter­penoids and a neoflavonoid 6.



A S R Anjaneyulu*, V Lakshmana Rao &

K Sreedhar








A minor phenolic alkaloid from Cocculus hirsutus Diels


IPC: Int.Cl.7 A 61 K 35/78 // A 61 K 31/05

Chemical investigation of the stems and roots of Cocculus hirsutus Diels (Menispermaceae) has yielded a new phenolic alkaloid corsutine 1 in addition to several previously reported compounds.



S B Yadav & Vyasji Tripathi*





Authors for correspondence are indicated by (*)

IPC: International Patent Classification

Int. Cl.: International Classification 7 edition, 1999