Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry


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VOL. 45B




Rapid Communication


Preparation of functionalised tetraphenylmethane derivatives via the Suzuki-Miyaura cross-coupling reaction


IPC Code: Int.Cl.8 C07C

A general methodology for the synthesis of various symmetrical and unsymmetrical tetraphenylmethane (TPM) derivatives is reported using the Suzuki-Miyaura (SM) cross-coupling reaction as a key step. The formation of an interesting self-coupling product during the SM cross-coupling reaction of mono-iodo tetraphenylmethane derivative is also observed.



Sambasivarao Kotha* & Manoranjan Behera











A facile [hydroxy(tosyloxy)iodo]benzene mediated synthesis of 2-arylimidazo[1,2-a]pyrimidines and their conversion into 3-bromo-2-arylimidazo[1,2-a]pyrimi­dines


IPC Code: Int. Cl.8 C07D

a-Tosyloxyketone 2, obtained through hypervalent iodine oxidation of enolizable ketones using [hydroxy­(tosyloxy)­iodo]benzene (HTIB) in acetonitrile, on treatment with 2-aminopyrimidine 3 generates regioselectively 2-arylimi­dazo[1,2-a]pyrimidine 6 which upon subsequent treatment with bromine undergoes electrophilic substitution at position-3 to yield 3-bromo-2-arylimidazo[1,2-a]pyrimidine 8.



Ranjana Aggarwal* & Garima Sumran















Synthesis of 3-amino-2-methyl/ethyl-5,6,7,8-tetrahydro­[1]­benzothieno[2,3-d] pyrimidin-4(3H)-one and its Schiff bases as possible antimicrobial and non-steroidal antiinflammatory agents


IPC Code: Int.Cl.8 C07D

 Hitherto unreported 3-amino-2-methyl-5, 6,7,8-tetra­hydro­[1]benzothieno[2,3-d]pyrimid-4 (3H)-one 3a and 3-amino-2-ethyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimid-4 (3H)-one 3b are prepared and treated with aromatic aldehydes to get Schiff bases 4a-l and 5a-l. The newly synthesized compounds are characterized by spectral analysis. All the compounds are screened for antibacterial and antifungal activity. Eight compounds are screened for their anti-inflammatory activity. A few of the compounds exhibit promising biological activity.



B Narayana*, B V Ashalatha, K K Vijaya Raj & N Suchetha Kumari








New heterocyclic derivatives of 3-formyl-4-hydroxy­coumarin


IPC Code: Int.Cl.8 C07D

The reaction of 4-hydroxy-2-oxo-2H-[1]benzopyran-3-carboxaldehyde with active methylene compounds under mild conditions results in the formation of 3, 6 and 9. The polyketomethylene compound 3 has been converted to pyrazoles 4a,b and isoxazole 4c by treatment with hydrazine, phenylhydrazine and hydroxylamine.




zeba N Siddiqui* & Mohammad Asad















Diastereoselective synthesis of 1,3-disubstituted 1,2,3,4-tetrahydro-b-carbolines using Pictet-Spengler reaction in non-acidic aprotic media


IPC: Int.Cl.8 C07D

Studies on the use of Pictet-Spengler reaction in non-acidic aprotic media for the diastereoselective synthesis of some tetrahydro-b-carbolines are reported.



S D Sharma*, Susmita Bhaduri & Gurpreet Kaur









An expeditious synthesis of 1,5-benzodiazepine derivatives catalyzed by CdCl2


IPC Code: Int.Cl.8 C07D

2,3-Dihydro-1H-1,5-benzodiazepines have been synthesized by the condensation of o-phenylenediamine and cyclic or acyclic ketones in the presence of CdCl2 as catalyst at
80–85şC temperature. The yields are high and the reactions go to completion within 10–20 min.



M A Pasha* & V P Jayashankara









Competing A1,3-strain and Ph:Ph diaxial repulsion in oximes and semicarbazones of N-nitroso-r-2,c-6-diphenylpiperidin-4-ones


IPC Code: Int.Cl.8 C07D

The configurations and preferred conformations of oximes 14-18 and semicarbazones 19-22 N-nitroso r-2,c-6-diphenylpiperidin-4-ones have been studied using NMR spectra and semiempirical MO calculations. The nitrosamines 14-22 are found to prefer twist-boat conformations.





R Vijayalakshmi, M Muthukumar, S Ponnuswamy*  & R Jeyaraman















An enantiospecific strategy to all four diastereomers of A-ring enyne synthon of 1a,25-dihydroxyvitamin D3


IPC Code: Int Cl.8 C07C

Enantiospecific syntheses of all the four diastereomers of the A-ring enyne synthon of 1,25-dihydroxyvitamin D3 is described.



A Srikrishna*, Santosh J Gharpure & P Praveen Kumar











Synthesis, antibacterial and antifungal activity of some new pyrido quinazolones


IPC Code: Int.Cl.8 C07D




V K Singh & V K Pandey*









Montmorillonite K10 clay catalyzed Friedlander synthesis of 1,8-naphthyridines in dry media under microwave irradiation


IPC Code: Int.Cl.8 C 07 D

1,8-Naphthyridines 3 are prepared expeditiously in a solventless operation by microwave thermolysis of 2-aminonicotinaldehyde 1 and carbonyl compounds containing a-methylene group 2 in the presence of benign reagent, montmorillonite K10 clay.



K Mogilaiah* & B Sakram















Kinetics of elimination reactions of 1-chloro-1-(4-methoxyphenyl)-2-phenylethane in acetonitrile


IPC Code: Int.Cl.8 C07D

Dehydrochlorination of 1-chloro-1-(4-methoxyphenyl)-2-phenylethane in acetonitrile follow unimolecular mechanism. The mass law effect and special salt effect observed confirm the E1 mechanism.



D Santhosh Kumar & S Balachandran*









Microwave promoted efficient synthesis of 2,5-disubstituted 1,3,4-thiadiazole


IPC Code: Int Cl8. C07D

A rapid and efficient method for the synthesis of substituted 1,3,4-thiadiazoles is described. The products have been characterized by analytical and spectral (IR and 1H NMR) data.



Tai-Bao Wei, Hong Liu, Jing-Han Hu, Man-Lin Li, Wei-Xia Xu, Li-Zi Yang & You-Ming Zhang*









Total synthesis of antibacterial dibromotyrosine derived alkaloid purpuramine-K


IPC Code: Int.Cl.8 C07C




S Malla Reddy, M Srinivasulu & Y Venkateswarlu*


















QSAR studies of 2,3-diarylpyrazolo[1,5-b]pyridazine analogs as cyclooxygenase-2 inhibitors


IPC Code: Int.Cl.8 C07D


2D-QSAR analysis study has revealed that the substitution of hydrophobic group in the 2,3-diaryl-pyrazolo[1,5-b] pyridazines at R2 position is favorable while substitution of bulkier group at R2 position is unfavorable for COX-2 inhibitory activity. In 3D-model, Mor14u and Mor29v are 3D-MoRSE code which have been calculated by summing atom weights viewed by a different angular scattering function contributed positively while G (O..O) is a conformational dependent descriptor and based on the geometry of the molecule contributed negatively to COX-2 inhibitory activity.











S Revathi, Arun Kumar Gupta, Love Kumar Soni,
S Kavitha, R Wagh & S G Kaskhedikar*









Electroreductive generation of (S)-(+)-N,N-dimethyl-2-(hydroxymethyl)-pyrrolidinium mercury compound for enantioselective synthesis of 2-amino-1-alkyl/aryl ethanols


IPC Code: Int.Cl.8C07D

(S)-(+)-N,N-Dimethyl-2-(hydroxymethyl)-pyrrolidinium (DMHP+)-mercury compound mediated enantioselective reduction of aminomethyl alkyl/aryl ketones in dimethyl­formamide-2-propanol (9:1) has been carried out using tetrabutylammonium tetrafluoroborate as a supporting electrolyte. The products viz. 2-amino-1-alkyl/aryl ethanols have been obtained in good yield (68-92%) with 35-91% optical purity and have been assigned (S)-configuration.





Ashok K Yadav* & Meera Manju









A high amylose starch isolated from the tubers of Curcuma aeruginosa


IPC Code: Int Cl8.A61K

NMR spectra of the starch, isolated from Curcuma aeruginosa in dimethyl sulphoxide-d6, contain groups of minor 13C, 1H, or O1H signals attributable to glycosyl end groups and the absence of other residues associated with branching in amylopectin molecules. 13C and 1H NMR spectral studies show that it is a high amylose starch. X-ray diffraction study reveal b-type polymorphic forms characteristic of high amylose starch.





C E Ranjini* & K K Vijayan















Conventional and ultrasound mediated synthesis of some thiadiazoles, triazoles and oxadiazoles


IPC Code: Int.Cl.8 C 07 D

Acid hydrazide 1 when treated with aryl isothiocyanates gave the compounds 2. These compounds 2 in acidic medium gave compounds 3 i.e. thiadiazoles and in basic medium gave compounds 4 i.e. triazoles. Compound 2 on treatment with I2/KI in NaOH gave compound 5 i.e. oxadiazoles.



S K Narwade, V B Halnor, N R Dalvi, C H Gill &

B K Karale*









New method for the synthesis of 1,3,5-triarylbenzenes


IPC Code: Int.Cl.8 C07D

Adsorbed on clayfen together with p-toluenesulfonic acid and catalytic amount of tin tetrachloride anhydrous (5%), aryl ketones are readily turned to 1, 3, 5 –triarylbenzenes in good yields upon exposure to microwaves under solvent-free conditions. A new method for the synthesis of poly substituted benzene is developed, which is simple and rapid.





Xiaobi Jing*, Feng Xu, Qihua Zhu, Xinfeng RenDong Li, Chaoguo Yan & Yaocheng Shi









Annual Index





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IPC: International Patent Classification

Int.Cl8.: International Classification, 8th Edition, 2006