Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry

Total visitors: 2,932  since 07-02-06

VOL. 45B




Rapid Communications





Cerium catalysed Michael addition to a,b-unsaturated oximes: A facile and efficient synthesis of substituted pyridines


IPC: Int.Cl.7 C 07 D

CeCl3.7H2O-NaI is found to be an effective catalyst for the synthesis of various tetra-substituted pyridine derivatives via Michael addition of b-dicarbonyl compounds to a,b–unsaturated oximes and subsequent ring closure by cyclo-dehydration of these products.






Sanjay Kumar, Anil Saini & Jagir S Sandhu*





Advances in Contemporary Research





Marine algal natural products: Contributions from India in the global context


IPC: Int.Cl.7 A 61 K 35/00

The review describes Indian contribution in the field of marine natural products in the global context. Several terpenes (mostly sesqui and diterpenes), steroids, ceramides, nitrogen pigments, heterocycles, aromatic compounds and polyethers have been reported from Indian marine algae.





Nittala S Sarma*, M Sri Rama Krishna & Sk G Pasha










Propionic acids in organic synthesis: Novel synthesis of benzimidazole, 3,1-benzoxazine, 3-aminoquinazoline and 3-aminothieno[2,3-d]pyrimidine derivatives containing 2-naphthyl propionyl moiety


IPC: Int.Cl.7 C 07 D

Naproxenoyl chloride 2 is reacted with some nucleophilic reagents as ammonium thiocyanate and sodium azide to produce the novel isothiocyanate 3 and azide 4 derivatives, respectively. The novel quinazolinone 11 was synthesized by acylation of methyl anthranilate with acid chloride 2 followed by treatment with hydrazine hydrate.





Abdullah G M Al-Sehemi*, A M Sh El-sharief &

Y A Ammar












Iodine (III) mediated synthesis of new 5-aryl-3-(4-hydroxy-6-methyl-2H-pyran-2-oxo-3-yl)-1-phenyl­pyra­zoles from dehydrogenation of 5-aryl-3-(4-hydroxy-6-methyl-2H-pyran-2-oxo-3-yl)-1-phenylpyrazolines


IPC: Int.Cl.7 C 07 D




Om Prakash*, Ajay Kumar, Mayank Kinger &

Shiv P Singh









A convenient stereoselective synthesis of β-d-gluco­pyra­nosides


IPC: Int.Cl.7 C 07 H 3/00

A simple, stereoselective synthesis of β-d-glucopyranosides via glycosidic bond has been reported.



Vishal Y Joshi & Manohar R Sawant*









Solvent-free improved syntheses of some substituted 1, 3-diaryl-propenones and 3,5-diaryl-6-carbethoxy­cyclo­hexenones under microwave irradiation and their antibacterial activity


IPC: Int.Cl.7 C 07 C

Substituted 1,3-diarylpropenones 3 and their trans­formation products 3,5-diaryl-6-carbethoxy­cyclo­hexenones 4 have been synthesized in improved yield using solvent-free solid phase microwave irradiation as compared to the conventional method and antibacterial activity of these have been evaluated.



Yajuvendra S Jhala, Shiv S Dulawat & B L Verma*












The reaction of aromatic aldehydes and 5,5-dimethyl-1,3-cyclohexanedione under solvent-free grinding conditions


IPC: Int.Cl.7 C 07 D

The reaction of aromatic aldehyde and 5,5-dimethyl-1,3-cyclohexanedione under grinding conditions has been catalyzed by KF/Al2O3 or silica sulfate and obtained two products:2,2-arylmethylene bis(3-hydroxy-5,5-dimethyl-2-cyclohexene-1-one) and 1, 8-dioxooctahydro- xanthene and their derivatives. In addition, the 2-amino-4-aryl-3-cyano-7,7- dimethyl-5-oxo-4H-5,6,7,8-tetrahydrobenzo[b]pyran can be obtained in this condition.



Tong-Shou Jin*, Ai-Qing Wang, Hui Ma,

Jian-She Zhang & Tong-Shuang Li









Quantitative structure activity relationship studies of diarylimidazoles as selective COX-2 inhibitors


IPC: Int.Cl.7 C 07 D

QSAR analysis has been performed on a series of diarylimidazole derivatives in order to gain further structural insights for developing newer COX-2 inhibitors.



M R Yadav*, D S Puntambekar, K P Sarathy,

S Vengurlekar & R Giridhar









Use of polyfunctionalized ethylene synthons: Convenient synthesis of biologically active tri­fluoro­methyl containing N-substituted-benzoyl­pyrazoles and triazole


IPC: Int.Cl.7 C 07 D

Several ethylene synthons have been used in the building of fluorine containing pyraazoles and their bioactivity is also reported.



Li Ming*, Wen Lirong, Wang Xiao, Yao Changsheng, Fu Weijun, Zhao Guilong,

Hu Fangzhong & Yang Huazheng














Synthesis and antiviral activities of N-substituted-2-substituted-benzimidazole derivatives


IPC: Int.Cl.7 C 07 D




Ashish Kumar Tewari* & Anil Mishra










Synthesis and antimicrobial evaluation of some 4- or 6-chloroisatin derivatives


IPC: Int.Cl.7 C 07 D // A 61 P 31/04, 31/10

Several semicarbazones and hydrazones of isomeric chloroisatins have been prepared and their in vitro antimicrobial properties against bacteria and fungi are reported.



S N Pandeya, A S Raja* & G Nath









Microwave thermolysis-Part IX: A selective and rapid oxidation of benzylic alcohols using clay supported ammonium nitrate


IPC: Int.Cl.7 C 07 C




H M Meshram*,B Muralidhar, B Eeshwaraiah,
K Ramesh Babu, D Aravind & J S Yadav









An efficient and chemoselective method for conversion of carbonyl compounds to 1,3-oxathiolanes with 2-mercaptoethanol catalyzed by TiCl4-montmorillonite


IPC: Int.Cl.7 C 07 D

Formation of 1,3-oxathiolanes from aldehydes and ketones using 2-mercaptoethanol in the presence of TiCl4-montmorillonite under mild reaction conditions in excellent yield is described. Chemoselective monothioacetalization of aldehyde in the presence of ketone can also be achieved in high yield.





Tong-Shou Jin*, Rui-Qiao Zhao, Yan-Ran Ma,

Mi-Na Yang, Jun-Jie Guo & Tong-Shuang Li















NMR and X-ray characterization of the diastereomeric pinacols derived from the photo-irradiation of o-alkoxy­acetophenones


IPC: Int.Cl.7 C 07 D

A simple 1H NMR characterization of diastereomeric pinacols derived from o-alkoxy-acetophenones is described. The 1H NMR spectral assignments are based on molecular modeling and substantiated by X-ray crystallographic structural assignment of a diastereomer.






Rajinder Singh, P K Garg, M S Hundal & M P S Ishar*









Reduction of aromatic nitro compounds using microwave heating assisted with alumina-supported hydrazine / Fe(NO3)3·9H2O


IPC: Int.Cl.7 C 07 C

Aromatic nitro compounds are easily reduced to the corresponding amino compounds using microwave heating assisted with hydrazine hydrate supported on alumina in the presence of Fe(NO3)3.·9H2O.





Chang-Rui Zhang & Yu-Lu Wang*









A facile synthesis and characterization of 2-(3˘,4˘-dihydrocarbazol-1˘-yl)-2,3,4,5-tetrahydroindolo­[2,3-b]azepanes


IPC: Int.Cl.7 C 07 D

Synthesis of 2-(3˘,4˘-dihydrocarbazol-1˘-yl)-2,3,4,5-tetra­hydro­­indolo[2,3-b]azepanes 2 by the reaction of 1-oxo-1,2,3,4-tetrahydrocarbazoles 1 in the presence of hydroxylamine hydrochloride and formic acid.



I Antony Danish & K J Rajendra Prasad*















Synthesis of pyrazolines, isoxazolines and amino­pyri­midines as biological potent agents


IPC: Int.Cl.7 C 07 D

Chalcones, 2-phenylamino-4-(4'-fluorophenylamino)-6-[4'-{3''-(phenyl/substituted phenyl /2'''-furanyl/3'''-pyridinyl)-2''-propenon-1''-yl} phenylamino]-s-triazines 6a-j have been prepared from ketone 5 based on s-triazine nucleus. These chalcones 6a-j on cyclisation with hydrazine hydrate, hydroxylamine hydrochloride and guanidine nitrate give the corresponding pyrazolines 7a-j, isoxazolines 8a-j and aminopyrimidines 9a-j, respectively. Antimicrobial activities of all synthesized compounds have been performed by using cup-plate method against bacteria and by using poisoned food technique against fungi.









Anjani Solankee* & Indrajit Thakor









Synthesis of new 1, 10-diethoxy-1H-pyrano[4, 3-b]quino­lines and their antibacterial studies


IPC: Int.Cl.7 C 07 D







a) R1=R2=R3=R4=H

b) R1=CH3, R2=R3=R4=H

c) R1=R2=R4=H, R3=OCH3

d) R1=R2=R4=H, R3=Cl

e) R2=R3=H, R1=R4=CH3





T Dhanabal, T Suresh & P S Mohan*















Synthesis of 5-arylidene-2-aryl-3-(benzotriazolo­aceta­midyl)-1,3-thiazolidin-4-ones as analegesic and anti­microbial agents


IPC: Int.Cl.7 C 07 D

Benzotriazole on reaction with ethyl chloroacetate affords 1, which on treatment with NH2NH2.H2O yields 2. Condensation of N1 (acetohydrazido) benzotriazole 2 with various carbonyls gives arylidene acetohydrazido benzotriazoles 3 which on cycloaddition with mercapto acetic acid yields the corresponding 4-thiazolidinones 4. Treatment of these 4-thiazolidinones with various carbonyl compounds afford 5-arylidene-2-aryl-3-benzotriazoloacetamidyl-1,3-thiazolidin-4-ones 5





K C Asati, S K Srivastava* & S D Srivastava









Synthesis and characterization of a new chromano­isoxazole


IPC: Int.Cl.7 C 07 D






Y L N Murthy*, Rani Nanda, K Ravi Kumar &

G Y S K Swamy









Synthesis of 2-(2-phenylethyl)chromones


IPC: Int.Cl.7 C 07 D

2-(2-Phenylethyl)chromones have been obtained by selective reduction of double bond of the styryl group in 2-styrylchromones involving catalytic hydrogen transfer reaction using ammonium formate in the presence of Pd-C.





Sharda Goel, Shashi & J K Makrandi*















Microwave assisted convenient and facile regeneration of carbonyl compounds from semicarbazones, phenyl­hydrazones and tosylhydrazones using phosphoric acid in solvent-free conditions


IPC: Int.Cl.7 C 07 D

Phosphoric acid is an efficient and mild reagent for regeneration of aldehydes from semicarbazones, phenylhydrazones and tosylhydrazones. The reactions have been carried out in solvent-free condition under microwave irradiation.





Krishna Banerjee, Alok Kumar Mitra &

Amarendra Patra*









Attempted synthesis of substituted carbazoles from 1-oxo-1,2,3,4-tetrahydro-carbazoles and 1-hydroxyimino-1,2,3,4-tetrahydrocarbazoles


IPC: Int.Cl.7 C 07 D

Synthesis of annelated carbazoles 2 and 4 by the reaction of 1-oxo-1,2,3,4-tetrahydrocarbazoles 1 and 1-hydroxyimino-1,2,3,4-tetrahydrocarbazoles 3 with vinyl acetate has been reported.







I Antony Danish & K J Rajendra Prasad*









A rapid microwave assisted synthesis of N, N'-diarylureas under solvent-free condition


IPC: Int.Cl.7 C 07 C

A novel microwave assisted phosgene-free synthesis of N,N˘-diaryl ureas under solvent free conditions has been described.




1a                            2                                                              3a




S Sarveswari & T K Raja*















Cytotoxic ent-kaurane diterpenoids from Isodon  racemosa (Hemsl) Hara


IPC: Int.Cl.7 C 07 C // A 61 K 35/00

A new ent-kaurane diterpenoid racemosin A (1) and three known compounds, leukamenin E (2), glaucocalyxin A (3) and wangzaozin A (4), have been isolated from the leaves of Isodon racemosa (Hemsl) Hara. Compounds 14 show significant cytotoxic activity against Bel-7402 and HO-8910 cells.











Lan Ding*, Guo-An Liu, Lai Wang, Kun Sun &

Han Wang









Synthesis of hexahydro-1,3,5-triazines: A new approach from N-substituted-a-aminoisothiocyanates


IPC: Int.Cl.7 C 07 C, C 07 D

Azomethines 1a-m react with ammonium thiocyanate/acetic acid to give the corresponding N-substituted-a-amino­isothiocyanates 2a-m which are found to be excellent starting materials for the synthesis of hexahydro-1,3,5-triazines 3a-m. Compounds 2a-m on treatment with toluene-2,4-diisocyanate give the corresponding hexahydro-1,3,5-triazines 3a-m in good yields.







Harish Kumar*, Rita Goyal, Anupama Parmar & Sukhwinder Kaur















Synthesis of 2-phenylimino-3-aryl-4-S-benzyl-6-hepta-O-acetyl-b-lactosylimino-2,3-dihydro-1,3,5-thiadiazine hydrochlorides


IPC: Int.Cl.7 C 07 D

2-Phenylimino-3-aryl-4-S-benzyl-6-hepta-O-acetyl-b-lactosylimino-2,3-dihydro-1,3,5-thiadiazine hydrochlorides 3 are prepared by the interaction of 1 with 2


R =

a: H

d: p-tolyl

g: p-Cl-phenyl


b: o-tolyl

e: o-Cl-phenyl



c: m-tolyl

f: m-Cl-phenyl



P V Tale & S P Deshmukh*









Selective oxidation of secondary over primary hydroxyl group


IPC: Int.Cl.7 C 07 C

Selective oxidation of oligoethylene glycol ether methyl 12(13)–hydroxy-13(12)-[11-hydroxy-3,6,9-trioxa-undecyl-1-oxy]-octadec-9-enoate 3 has been studied using pyridinium chlorochromate (PCC). The reaction has resulted in the formation of methyl 12(13)–oxo-13(12)-[11-hydroxy-3,6,9-trioxa-undecyl-1-oxy]-octadec-9-enoate 5 as an unexpected product wherein only the secondary hydroxyl group has been oxidized while the primary hydroxyl group has remained intact.




Sukhprit Singh* & Vandana Mahajan












Trimethylammonium fluorochromate (TriMAFC): A convenient new and mild reagent for oxidation of organic substrates


IPC: Int.Cl.7 C 07 C






S A Seyed Sadjadia & S Ghammamy*b









Synthesis of pyrazolines promoted by Amberlyst-15 catalyst


IPC: Int.Cl.7 C 07 D

The synthesis of substituted pyrazolines in good yield by the cyclization of propenones using Amberlyst–15 catalyst is described. The method affords a cheap, nontoxic and ecofriendly means of synthesizing pyrazoline derivatives. The method also enables the recovery of the catalyst and the solvent used without any difficulty.



B Shivarama Holla*, M Mahalinga, Boja Poojary, Mithun Ashok & P M Akberali



Authors for correspondence are indicated by (*)

IPC: International Patent Classification

Int. Cl7.: International Classification, 7th Edition, 1999