Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry

Total visitors: 2,791  since 24-03-06

VOL. 45B


MARCH 2006


Rapid Communications





Synthesis and characterization of novel (fenchonyl­sulfonyl) oxaziridine


IPC: Int.Cl.7 C 07 D

An efficient synthesis of (fenchonylsulfonyl) oxaziridine from commercially available fenchone is described. Several intermediates involved in the synthesis of oxaziridine viz. fenchone sulfonic acid, fenchone sulfonylchloride, fenchone sulfonamide, fenchone sulfonimine have also been synthesized and characterized.









Jitendra Kumar Mishra, Vinod Kumar &
Mahabir Parshad Kaushik*









Soluble polymer supported organic synthesis (SPSOS): Synthesis of PEG-ylated phthalizinediones


IPC: Int.Cl.7 C 07 D

PEGylated phthalizine derivatives of different molecular weights have been synthesized after the activation of PEGs using glutaric anhydride. Percentage loading has been calculated using 1H NMR.






Kalyan Chakravarthy Akula*, Krishna Boddu & Udayasree Doma















AlCl3 mediated three component cyclocondensation for the synthesis of 5-unsubstituted 3,4-dihydropyrimidin-2(1H)-ones


IPC: Int.Cl.7 C 07 D

5-Unsubstituted-3,4-dihydropyrimidin-2(1H)-ones have been synthesized in excellent yields in aluminium trichloride mediated three component cyclocondensation of aldehyde, urea and enolisable ketones.









Anil Saini, Sanjay Kumar & Jagir S Sandhu*











Synthesis and antimicrobial activity of some new
1-substituted-3-pyrrolyl aminocarbonyl/oxadi­azolyl/­tri­azolyl/5-methoxy-2-methylindoles and benz[g]indoles


IPC: Int.Cl.7 C 07 D












Dundappa S Donawade, A V  Raghu &

Guru S Gadaginamath*















Synthesis and antifungal activity of N-(alkyl/aryl)-2-(3-oxo-1,4-benzothiazin-2-yl)acetamide


IPC: Int.Cl.7 C 07 D

A series of N-(alkyl/aryl)-2-(3-oxo-1,4- benzothiazin-2-yl)acetamide have been synthesized by condensation of substituted amines with maleic anhydride followed by cyclization with o-ATP. All the synthesized compounds 7a-z have been tested for their antifungal activity. The structures of the synthesized compounds have been established on the basis of elemental analysis and spectral data.







G Gupta* & S B Wagh









Synthesis and screening of 5-carbethoxy-N-aryl-4, 6-dimethyl-1,2-dihydropyrid-2-ones as chemical hybridi­sing agents for wheat (Triticum aestivum L.)


IPC: Int.Cl.7 C 07 D

5-Carbethoxy-N-aryl-4,6-dimethyl-1,2-dihydropyrid-2-ones have been synthesized by the condensation between substituted anilines with ethyl isodehydracetate and evaluated as chemical hybridising agents on wheat. The substituents at para position have a positive effect on induction of male sterility. The observed induction of male sterility can be explained by the negative influences of ΣMR and positive contributions of Fp.










Kajal Chakraborty* & C Devakumar















Synthesis and antioxidant activities of some 4-benzyl­idenamino-4,5-dihydro-1H-1,2,4-triazol-5-one derivatives


IPC: Int.Cl.7 C 07 D

Eight 3-alkyl(aryl)-4-(3,4-dihydroxybenzyliden-amino)-4,5-dihydro-1H-1,2,4-triazol-5-ones have been synthesized and their antioxidant activities are investigated. In addition, the pKa values of the newly synthesized compounds are determined in four non-aqueous solvents.



Haydar Yüksek*, Sevgi Kolaylı, Murat Küçük,

M Ozgün Yüksek, Ummuhan Ocak, Esra Şahinbaş,
Efecan Sivrikaya
& Miraç Ocak









Studies in amine oxide rearrangement: Meisenheimer  rearrangement of m-substituted tertiary amine oxides


IPC: Int.Cl.7 C 07 D




K C Majumdar*, B Roy, P K Basu & P Biswas









Kinetic study of hydrolytic decomposition of organo­phosphates and thiophosphate by N-hydroxyamides in cationic micellar media


IPC: Int.Cl.7 C 07 D












R1 = R2 = C6H5, Z = O, PNPDPP;         R1 = R2 = C2H5, Z= O, PARAOXON

R1 = R2 = C2H5, Z = S, PARATHION;  Nu– = N-hydroxyamides



Kallol K Ghosh*, Daliya Sinha, Manmohan L Satnami, A K Shrivastava, D K Dubey  & G L Mundhara









A simple synthesis of azuleno[1,2-c]thiophenes by reactions of 1-acyl-2-(bromomethyl)azulenes with thioamides


IPC: Int.Cl.7 C 07 D

Azuleno[1,2-c]thiophenes are obtained by using simple method from 1-acyl-2-(bromomethyl)azulene  prepared from acylation and bromination of 2-methylazulene in good yields.





J R Hou*, D L Wang  & Imafuku Kimiaki















Synthesis, antibacterial and surface activity of 1,2,4-triazole derivatives


IPC: Int.Cl.7 C 07 D

Sodium 1-[4-amino-5-mercapto-4H-(1,2,4)triazol-3-yl]-heptadecane-1-sulfonate 2 has been used as a precursor for synthesis of novel 1,2,4-triazole derivatives through reaction with different reagents under different reaction conditions.



Refat El-Sayed









Antimicrobial screening and synthesis of some novel benzo[a]phenothiazines and ribofuranosides


IPC: Int.Cl.7 C 07 D

6-(2-Methoxy-4-chloro-5-methylanilino/2-methoxy-5-methyl­anilino)-9-chloro-5H-benzo[a]phenothiazin-5-ones give various benzo[a]phenothiazines derivatives which upon condensation with b-d-ribofuranosyl-1-acetate-2,3,5-tri­benzoate yield the desired ribofuranosides.





Neeraj Kumar, Anoop K Sharma, Reshu Garg &

Ashok K Yadav*















Synthesis of 1,5-benzothiazepines: Part XXX ¾ Synthesis and antimicrobial studies of 10-substituted-6a, 7-di­hydro-6H -7-(4-fluorophenyl)-6-phenyl [1] benzopyrano [3,4-c] [1,5] benzothiazepines


IPC: Int.Cl.7 C 07 D





Umesh C Pant*, Hem Chandra, Shweta Goyal, Priyanka Sharma & Seema Pant









Mass spectral analysis and X-ray structure of diethyl 2-[aryl(4-aryl-1,2,3-selenadiazol-5-yl)methyl]malonate


IPC: Int.Cl.7 C 07 D

The mass spectra of diethyl 2-[aryl(4-aryl-1,2,3-selenadiazol-5-yl)methyl] malonate have been studied under electron impact method by high resolution mass spectrometry. The X-ray study on a representative compound is also investigated.



Sivaperuman Saravanan,

Shanmugam Muthusubramanian* & Kurt Polborn









Polymeric sulfonate of piperazine as an inexpensive and recyclable catalyst for Knoevenagel condensation


IPC: Int.Cl.7 C 07 D

Polymeric sulfonate of piperazine (Amberlite® 200 H/ piperazine) has been found to be an inexpensive and reusable catalyst for Knoevenagel reaction.





Xinmin Wen















QSAR studies on biological oxygen demand of alcohols


IPC: Int.Cl.7 C 07 C

Biological oxygen demands of some alcohols are modeled by using topological parameters along with a novel parameter, ThOD.







Minati Kuanar, Saroj K Kuanar, Sabita Patel &

B K Mishra*








Synthesis of pyrimidine based thiazolidinones and azetidinones: Antimicrobial and antitubercular agents


IPC: Int.Cl.7 C 07 D

Several pyrimidine based thiazolidinones and azetidinones have been synthesized and tested for their antimicrobial and antitubercular activities.












R B Patel, P S Desai, K R Desai & K H Chikhalia*















Solid-state induced heterocyclization under microwave irradiation: Synthesis of 2-phenyl-3-hydroxy-quinolin-4(1H)-one


IPC: Int.Cl.7 C 07 D










Majid M Heravi*, Hossein A Oskooie, Lila Bahrami & Mitra Ghassemzadeh









Is ab initio DFT method useful in analyzing sequence specificity of bases in nucleic acid?


IPC: Int.Cl.7 C 07 D

The stacking interaction of base pairs in DNA has been studied by using DFT method. The interaction energies of optimum stacked sequences are useful for analyzing sequence specificity qualitatively. However, the energy values obtained from this method are not accurate due to the exclusion of dispersion interaction.






Stacked AT-AT structure






Raghab Parajuli, Rituraj Kalita & C Medhi*















Synthesis of 4H-imidazo[2,1-c][1,4]benzo­xazin-4-yl acetic acids and esters as possible COX-2 inhibitors


IPC: Int.Cl.7 C 07 D

A series of 4H-imidazo[2,1-c][1,4]benzoxazin-4-yl acetic acids and esters (7 and 8) have been synthesized from methyl a-(3,4-dihydro-3-oxo-2H-1,4-benzoxazin-2-yl) acetates 5 and their COX-2 inhibition activities are evaluated.













K N Jayaveera, S Sailaja, P Reddanna,

D Bharat Reddy, G Jagath Reddy* & K Srinivasa Rao









1-Benzyl-4-aza-1-azonia-bicyclo[2.2.2]­octane tri­bro­mide as a regenerable an useful reagent for bromination of phenols under mild conditions


IPC: Int.Cl.7 C 07 D
















Abdol R Hajipour*, Seied A Pourmousavi &

Arnold E Ruoho


















Lipid derivatives from Mucuna pruriens seeds


IPC: Int.Cl.7 C 07 C

Fatty acids  and the lipid  derivatives 1-3 have been identified by  spectroscopic methods from the n-hexane extract of the seeds of M. pruriens.



2, R=H

2a, R=Ac

3, R=H

3a, R=Me


Laxminarain Misra* & Hildebert Wagner









Microwave assisted rapid and efficient synthesis of 2,1-benzoisoxazoles


IPC: Int.Cl.7 C 07 D

A simple extremely fast and high yielding protocol has been developed for the synthesis of 2,1-benzoisoxazoles under microwave irradiation.



E Rajanarendar*, E Kalyan Rao & D Karunakar









Michael adducts – Synthons for a new class of 1,4-dispirocyclohexane derivatives


IPC: Int.Cl.7 C 07 C

A new class of 1,4-dispirocyclohexane derivatives have been prepared from 2,6-diaroyl-3,5-diarylcyclohexane-1,1,4,4- tetracarboxylic acid tetramethyl ester.



V Padmavathi*, B Jagan Mohan Reddy, D R C Venkata Subbaiah & A Padmaja











Direct oxidative deprotection of trimethylsilyl ethers with cerium ammonium nitrate supported onto HZSM-5 zeolite under microwave irradiation in solventless system


IPC: Int.Cl.7 C 07 C

Trimethylsilyl ethers are selectively and rapidly oxidized to the corresponding carbonyl compounds by cerium ammonium nitrate (CAN) supported onto HZSM-5 zeolite under microwave irradiation in solvent free conditions.



Hossein A Oskooie*, Somaih Solemani Amiri,

Majid M Heravi, Shahnaz Khaleghi &

Mitra Ghassemzadeh









Aza-crown ether tethered with benzothiazole: Synthesis and optical spectral studies


IPC: Int.Cl.7  C 07 D




Sabir H Mashraqui*, Vashi Dhaval, S Subramanian & Tabrez B Khan









A convenient synthesis of xyridin A metabolite from Xyris indica L.


IPC: Int.Cl.7 C 07 D

A convenient synthesis of xyridin A 1a has been carried out.



Hafiz Badar-ud-Din Ahmed, Nasim Hasan Rama*,

Muhammad Aslam Malana & Ghulam Qadeer















Microwave assisted rapid and efficient synthesis of aryl methyl ketones and β-keto esters using Meldrum’s acid †


IPC: Int.Cl.7 C 07 D

Microwave mediated rapid and efficient synthesis of aryl methyl ketones and β-keto esters from acyl Meldrum’s acid by hydrolysis and alcoholysis, respectively, has been reported.



d H More & P P Mahulikar*









A convenient method for the oxidation of Hantzsch 1,4-dihydropyridines with N-bromo succinimide


IPC: Int.Cl.7 C 07 D 211/00

A convenient and mild method for  conversion of  Hantzsch 1,4-dihydropyridines to pyridines using NBS at room temperature in excellent yields is described.


R = H, CH3, 2-Furyl, CH3-C6H4, NO2-C6H4, CH3O-C6H4


R Nagarajan, J C A Anthonyraj, D Muralidharan,

C Saikumar & P T Perumal*









Synthesis of 4-aryl-5-hepta-O-acetyl-β-d-lactosylimino-3-tetra-O-benzoyl-β-d-glucopyranosylimino-1,2,4-dithi­azolidine hydrochlorides


IPC: Int.Cl.7 C 07 D

4-aryl-5-hepta-O-acetyl-β-d-lactosylimino-3-tetra-O-benzoyl-β-d-glucopyranosylimino-1,2,4-dithiazolidine hydro­chlo­rides 4a-g were prepared by reaction of 2 with 3.


R=3-4a, phenyl; b, o-tolyl; c, m-tolyl; d, p-tolyl; e, o-chloro; f, m-chloro; g, p-chloro.

Bz = -COC6H5, Ac = -COCH3


M G Dhonde, P V Tale & S P Deshmukh*





Authors for correspondence are indicated by (*)

IPC: International Patent Classification

Int. Cl7.: International Classification, 7th Edition, 1999