Indian Journal of Chemistry


Sect. B: Organic Chemistry including Medicinal Chemistry


Total visitors: 23  since 12-12-06



VOL. 45B






Rapid Communications







An efficient ring-closing metathesis reaction based
approach to 1,2,2-trimethylcyclopentane-methanol. Formal synthesis of (
±)‑herbertene and (±)‑cuparenes


IPC: Int.Cl.8 C07C

Formal total synthesis of aromatic sesquiterpenes
hebertene and cuparene employing a Claisen rearrange-ment-RCM based strategy is reported.










A Srikrishna* & G Satyanarayana












Substituent directed distal photoisomerisation of indolic dienyl  chromophores


IPC: Int.Cl.8 C07D

Photoisomerisation in indolic dienyls is controlled by the substituents present on the indolic nitrogen atom.






Anil K Singh* & Prasanta K Hota














Asymmetric induction in copper (I)-catalyzed
intramolecular [2 + 2] photocycloaddition: Synthesis of enantiopure cyclobutane derivatives


IPC: Int.Cl.8 C07C

Asymmetric induction in copper (I)-catalyzed intramolecular [2+2] photocycloaddition of 1,6-dienes to produce enantiopure oxa-bicyclo[3.2.0]heptane derivatives has been achieved. A novel anion-induced cleavage of the tetrahydrofuran ring in these oxa-bicyclo[3.2.0]heptane derivatives has led to a convenient access to the synthetically useful cis-1,2-disubstituted cyclobutanes in enantiomerically pure form.













Niladri Sarkar & Subrata Ghosh*












Phase-transfer catalyzed acylation of 5(3)-hydroxy-3(5)-substituted-1H-pyrazoles


IPC: Int.Cl.8 C07D

PTC-acylation of 5(3)-hydroxy-3(5)-substituted-1H-pyrazoles by different acyl halides reagents under PTC- conditions has been investigated. This work is aiming to study the comparative reactivity of N- versus O- versus C-acylation.













A Kh Khalil, M A Hassan*, M M Mohamed & A M El-Sayed











The theoretical conformation analyses of polyoxanorbornene chain


IPC: Int.Cl.8 C07C

The conformational analysis of polyoxanorbornene (PONB) chain is investigated with the AM1, MM2, AMBER and OPLS methods taking into consideration the possibility of binding of oxanor- bornene monomers to each other at various positions, i.e. exo-exo, exo-endo, endo-endo.






                           exo-exo(A)(TCTC)                       exo-endo(B)(TGTG-)                             endo-endo(C)(TCTC)




                    exoexo-endoendo(D)(TGTG-)                                    exoexo-endoexo-endoendo-exoendo(E)(TGTG-)2







Sevil Savaşkan Yılmaz & Rıza Abbasoğlu*












Exploring QSAR of peripheral benzodiazepine receptor binding affinity of 2-phenylpyra-zolo[1,5-a]pyrimidin-3-yl-acetamides using topological and physicochemical descriptors


IPC: Int.Cl.8 C07D

The present QSAR study has attempted to explore the structural and physicochemical requirements of 2-phenyl-pyrazolo[1,5-a]pyrimidin-3-yl-acetamides for binding with peripheral benzodiazepine receptor.














Manoj Kumar Dalai, J Thomas Leonard & Kunal Roy*












Synthesis, antimicrobial and antiinflammatory activities of 1,3,4-oxadiazoles linked to naphtho[2,1-b]furan


IPC: Int.Cl.8 C07D

Condensation of naphtho[2,1-b]furan-2-carboxyhydrazide 1 with different aromatic aldehydes affords the corresponding arylidene derivatives 2a-h. These compounds undergo
cyclization with acetic anhydride and mercuric oxide to yield 3a-h and 4a-h respectively. The compound 1 on refluxing with carbon disulphide and ethanolic potassium hydroxide followed by acidification furnish 5. It is converted into
Mannich bases 6a-h by treatment with  formaldehyde and appropriate  aromatic  amines. The selected  compounds have  been screened for their antimicrobial and anti-inflammatory ativities. The compound 4f has exhibited considerable antimicrobial activity and the compound 4c showed significant anti-inflammatory activity.






K C Ravindra, H M Vagdevi*, V P Vaidya &
Basavaraj Padmashali












Synthesis of chemiluminescent naphtho[1,8-de][1,2]diaze-


IPC: Int.Cl.8 C07D

A new chemiluminescent seven membered cyclic peri
hydrazide and five of its biotin conjugates with various spacer groups are synthesized. The total framework of the chemiluminescent biotin conjugates is constructed taking advantage of a convergent synthesis from various stable intermediates employing DCC condensation and NHS activation.





N V KrishnaMurthy & A Ram Reddy*












Synthesis and investigation of mass spectra of
3-substituted-2-thioxo-imidazolidin-4-one derivatives


IPC: Int.Cl.8 C07D

3-Substituted-2-thoxo-imidazolidin-4-one 2 is prepared via cyclization of compound 1 with ethyl chloroacetate in the presence of fused sodium acetate. The mass spectral fragmentation pattern of some of the prepared compounds are described.











M E Abd El-Fattah









Synthesis and biological evaluation of ureido derivatives as VLA-4 antagonists


IPC:.Int.Cl.8 C07D

Synthesis of new compounds as VLA-4 antagonists based on bioisosteric replacements of ureido and amido moieties and their biological evaluation are reported.







V J Sattigeri*, A Soni, L K Gupta, A Ray, S Ahmad,
J B Gupta & M Salman














N-Octyl quinolinium tribromide. A task specific quinoline based ionic liquid as a new brominating agent


IPC: Int.Cl.8 C07D






M P Kaushik*  & Vivek Polshettiwar












Lewis acid promoted synthesis of 2(3H)-benzofuranones


IPC: Int.Cl.8 C07D

A Lewis acid promoted one-step synthesis of 2(3H)-benzofuranones via an intramolecular rearrangement of the corresponding substituted O-methoxyacetyl benzenes and coumarins is described.











B Ravindra Babu, Shilpika Bali, Rajeev Sakhuja & Subhash C Jain*












A simple synthesis of a-methyl-g-keto acids


IPC: Int.Cl.8 C07C









Bharati Pawar & Pradip Lokhande*












Oxidative regeneration of carbonyl compounds from their oximes using in situ generated superoxide


IPC: Int.Cl.8 C07C

Superoxide ion, generated in situ by the phase transfer reaction of potassium superoxide and 18-crown-6, brings about an easy oxidative regeneration of a variety of carbonyl compounds from their oximes under significantly mild reaction conditions at room temperature.
















K N Singh*, Jyotsna Pandey & Manorama Singh












Bioactive diterpenes from the mangrove Avicennia officinalis Linn


IPC: Int.Cl.8 A61K

From the hexane and ethyl acetate extracts of A. officinalis, known diterpenes including rhizophorin-B 1 and a new diterpene 2 have been isolated and their antimicrobial activities have been evaluated.










C Subrahmanyam, S Ratna Kumar &

G Damodar Reddy












Synthesis, insecticidal and antimicrobial activities of some heterocyclic derivatives of quinazolinone


IPC: Int.Cl.8 C07D

Some new 4-phenyl-2,3-dihydro-6-(substitutedaminoethyl)-10-iodo[1,2,4]-triazino[2,3-c]-quina-zolin-5-ones 6-14 have been synthesized from 4-(phenyl-2,3-dihydro-6-methyl-10-iodo [1,2,4]-triazino[2,3-c]quinazolin-5-one 5 by introducing different heterocyclic nuclei. Compounds 5 and 6-14 have been screened for insecticidal, anti-fungal and antibacterial activities. Compound 4-phenyl-2,3-dihydro-6-(b-naphthyl-aminoethyl)-10-iodo[1,2,4]-triazino[2,3-c]-quinazolin-5-one 14
has been found to be the most potent compound of the present study which shows mortality of insects at 190.6 min while standard compounds exhibit at 280 min at a concentration of 5 g/L. Moreover, this compound also possesses anti-bacterial activity. The structure of these compounds have been elucidated by IR, 1H NMR, mass spectroscopy and elemental analysis.







6 - 14






Tripti Singh*, Shalabh Sharma,
Virendra Kishore Srivastava & Ashok Kumar












Chemical study on Garhwal Himalayan Lichen Usnea emidottertis


IPC: Int.Cl.8 C07C

Usnea species are medicinally important species so we take unexplored, Usnea emidotteris. Seven components 2- hydroxy-3-methoxy-4,6-dimethyl ethyl benzoate, 2,4-dihydroxy-3,6-dimethyl ethyl benzoate, 2-hydroxy-4-methoxy-3,6-dimethylbezoic acid, usnic acid, barbatic acid, diffractaic acid and evernic acid are isolated first time from Usnea emidotteries and identified from their physicochemical data.







4                                                                                                  5



6                                                                                               7




M S M Rawat*, Vertika Shukla, Sandeep Negi & G Pant












Microwave induced, solvent-free Knoevenagel condensation of 4-oxo-(4H)-1-benzopyran-3-carbaldehyde with Meldrum’s acid using alumina support


IPC: Int.Cl.8 C07D

A rapid, solvent-free and environmentally friendly Knoevenagel condensation reaction of 4-oxo-(4H)-1-benzopyran-3-carbaldehyde 1 with Meldrum’s acid 2 has been carried out under microwave irradiation by using acidic alumina support.







S S Shindalkar, B R Madje & M S Shingare*












Isolation of chalkones from the seeds of Psoralea corylifolia Linn.


IPC: Int.Cl.8 A61K

Isolation and characterization of a new chalkone namely 4,2–dihydroxy–2’’–(1’’’–methyl ethyl)–2’’–3’’–dihydro–(4’’,5’’,3,4) furano chalkone 1 along with a known chalkone 4,2–dihydroxy–4–methoxy–5–(3’’’,3’’’–dimethyl allyl)–chalkone 2 have been carried out from the seeds of the desert variety of Psoralea corylifolia Linn.









Deepshikha Agarwal, S P Garg & Pramilla Sah*












Correlation between the pKa and pharmacological properties of some imidazolin–5(4H)-ones, their precursors and Schiff’s bases







IPC: Int.Cl.8 C07D

The pKa value of some synthesized imidazolin-5(4H)-ones and their precursors, Schiff’s bases are determined by potentiometric method and the analgesic activity and CNS depressant property are evaluated, which are correlated with the pKa values. It is found that a correlation is established in best fit curve of 3rd order polynomial equation.








J K Gupta, Biplab De* & V S  Saravanan







Authors for correspondence are indicated by (*)


IPC: International Patent Classification

Int.Cl8.: International Classification, 8th Edition, 2006