Indian Journal of Chemistry

Sect. B : Organic Chemistry including Medicinal Chemistry

VOL. 42B






Rapid Communications



A facile synthesis of 5-arylpyrazolo[4,3-d]-pyrimidin-7-ones

A series of 1-methyl-3-propylpyrazolo[4,3-d]-pyrimidin-7-ones substituted in the 5-position with various aryl substituents has been synthesized by the reaction of corresponding Schiff bases with 4-amino-1-methyl-3-propylpyrazole-5-carboxamide in the presence of acetic acid.





T V Maruthikumar & P Hanumantha Rao*














Polymer supported palladium (II) complexes as hydrogenation catalysts

An approach towards immobilization of soluble palladium(II) complexes in polymer matrices  and their behaviour as hydrogenation catalysts are reported.





Debkumar Mukherjee









Synthesis of isoxazolyl pyrimidine diones and isoxazolyl thiazolidinones


A series of 3-phenyl/methyl-1-(3-methyl-5-styryl/ substituted styryl-4-isoxazolyl)-2,3-dihydro-2-thioxo-4,6 (1H, 5H) pyrimidinediones 3 and 3-(3-methyl-5-styryl/substituted styryl-4-isoxazolyl)-2-phenyl/methyl-imino-4-thiazolidinones 4 have been prepared from isoxazolyl thioureas 2 on treatment with malonic acid and chloroacetic acid respectively.





E Rajanarendar*, Md Afzal & D Karunakar





Synthesis and reactions of pyranoquino­lines

Novel hetrocyclic compounds 6a-c, 7a-c, 8a-c and 9a-c have been prepared starting from 6-amino­cou­marins.and ethyl benzoylacetate.



V V Mulwad* & M B Dalvi








Synthesis, characterization and electrochemical behaviour of some substituted 3-arylazo-8-aldehydo-4-methylcoumarins at dropping mercury and glassy carbon electrode


Synthesis, characterization and comprehensive electrochemical studies on 3-arylazo-8-aldehydo-4-methyl cou­marins have been reported.



Ashok Kumar*, Partibha Sharma & Ravi Sharma








Copper (II)-b-cyclodextrin aided oxidation of eugenol

The reaction with eugenol [3-(4-hydroxy-3-methoxy­phenyl)-prop-1-ene] in presence of Cu(II)-b-CD or b-CD or HPb-CD or CuSO4 is carried out in acetic acid solvent to which H2SO2 is added at room temperature. Cu(II)-b-CD gives the highest yield of an oxidized product.


H H Pattekhan & S Divakar*







Azole compounds designed by molecular modell­ing show antifungal activity as pre­dicted

Several azole compouns have been designed .by molecular modeling techniques and synthesized and tested for antifungal activity. Some compounds show excellent activity in vitro. The results are consistent with the computational findings.


Rajeshri G Karki, Vijay M Gokhale,
Prashant S Kharkar & Vithal M Kulkarni*









Synthesis and biological activity of cyanopyridine, isoxazole and pyrazoline derivatives having thymol

Several new 4-acetoacetamido thymol 1, 4-(substi­­tuted benzal aceto acetamido) thymols 2a-j, 4-(2˘-amino-3˘-cyano-4˘-aryl-pyridin-6˘-yl- acetamido)­thy­mols 3a-j, 4-(5˘-aryl-isoxazol-3˘-yl-acetamido)­thy­mols 4a-j, and 4-(1˘-N(H)/N-acetyl-5˘-aryl-pyra­zolin-2˘-yl-acetamido) thymols 5a-t have been synthesized.


J M Desai & V H Shah*









Triterpenoid saponin from Abrus precatorius (Fabaceae)

New triterpenoid saponins isolated from the aerial parts of Abrus precatorius and identified as olean-12-ene-3b, 23, 28-trihydroxy-3-O-{[b-d-glu­­co­pyr­a­­no­syl-(1®4)-b-d-gluco­pyranosyl-(1®3)]-b-d-glu­­­­­co­­pyranosyl-(1®2)]-b-d-fucopyranoside 1 and olean-12-ene-3b, 16b, 23, 28-tetrahydroxy-3-O-{[b-d-glucopyranosyl-(1®4)-b-d-gluco­pyranosyl-(1®3)]-[b-d-glucopyranosyl-(1®2)]-b- d-fuco­pyranoside} 2.


Edet M Anam








One-pot synthesis of dimethyl 2-[acyl(1-naph­thyl)­amino]-3-(1,1,1-triphenyl-λ5-phos­pha­nyli­dene)succinates

A  single-step synthesis of highly stabilized ylides 7 is described.


Ali Ramazani*, Leila Karimi-Avargani & Farideh Gouranlou









Synthesis of 2-quinazolinonylimidazoli­dinones

A linear synthesis of 2-quinazolinonylimida­zolidi­no­nes 5 from 2-chloromethyl-3-methyl­quinazolin-4(3H)-ones 1 is reported.


P S N Reddy*, P Pratap Reddy & T Vasantha









Synthesis and structural studies of novel 1,3,4-oxadiazolophanes

The title compounds have been prepared in moderate yields from 2,5-bis-(2-hydroxyphenyl)-1,3,4-oxadia-zole 2. The title compounds have also been studied for their use as PTC agents.


Madhukar S Chande*, Ajit A Godbole,
Evans Coutinho & Prashant Desai









Heterocyclic systems containing bridgehead nitrogen atom: Synthesis and bioactivity of 3-(2-thienyl)-s-triazolo[3,4-b][1, 3, 4]thia­dia­zole, 2-(2-thienyl)thiazolo[3,2-b]-s-­triazole and isomeric 3-(2-thienyl)thiazolo[2,3-c]-s-triazole

The synthesis of 2-(2-thienyl)-5-p-bromophenyl­thiazolo[3,2-b-]-s-triazole 5,5-(p-bromophenyl)-3-(2-thienyl)thiazolo[2,3-c]-s-triazole 7 and 3-(2-thienyl)-s-triazolo[3,4-b][1,3,4]thiadiazole-6(5H)-thione 9 has been achieved.


Jag Mohan










Quinolinium chlorochromate as an efficient reagent for oxidative cleavage of oximes via the use of microwave irradiation and pestle/mortar

Microwave radiation and pestle/mortar techniques have been employed successfully in the presence of quinolinium chlorochromate for the regeneration of carbonyl compounds from the corresponding oximes.




Jasvinder Singh*, Monica Bhandari,
Jasamrit Kaur & Goverdhan L Kad







Montmorillonite K10 – AlCl3 catalyzed enolization: A bifunctional system for selective bromination of hydroxy­aceto­phenones




Vinod Rama Uchil & Vidya Joshi*









Stereoisomeric synthesis of oxazolidinone and fused pyrrolidine derivatives via azomethine ylides and their antimicrobial activity

The reaction of isatin with 1,2,3,4-isoquinoline-3-carboxylic acid gives rise to azomethine ylide which undergoes [3+2] cycloaddition with various dipolarophiles to afford spiro oxazolidinone and pyrrolidine derivatives.



P Pardasani*, R T Pardasani,
V Chaturvedi & A Saxena










Synthesis and antimicrobial screening of N-substituted –3-chloro-4-dithiocarbamato azetidin-2-ones

Synthesis and antibacterial screening studies of  substituted 3-chloro-4-dithiocarbomatoazetidin-2-ones.


Ashok Kumar*, Pratibha Sharma,
Ravi Sharma & Pankaj Mohan









Synthesis of isoxazoles and quinoxalines as potential anticancer agents

Preparation of isoxazoles 2a-l and quinoxalines 3a-l from different chalcones 1a-l , has been reported. The compounds have been evaluated for their anticancer and antimicrobial activity.


N A Vekariya, M  D Khunt & A R Parikh*









Synthesis of biologically active angularly fused bisaroylbenzodifurans by PTC and solvent free microwave irradiation




K S Krishna Murthy, B Rajitha &
M Kanakalingeswara Rao*







Microwave assisted acetylation and deacetyla­tion studies on the triterpenes isolated from Dysoxylum malabaricum and Dysoxylum beddomei

Conventional acetylation and  deacetylation in triterpenes are found to give good yields within a mater of seconds when conducted in the presence of microwave radiation. Lupane,cycloartane and tirucallane triterpenes are examined.


G Jayakumar*, M D Ajithabai, B Santhosh,
C S Veena & Mangalam S Nair









1-(2˘,6˘-Dihydroxyphenyl) -b-d-glucopyrano­side, a  novel C-glycoside from  Pterocarpus marsupium

Isolation and  characterisation of a novel  C-glycoside, 1-(2˘,6˘-dihydroxyphenyl) -b-d-glucopyranoside 1 from Pterocarpus  marsupium  Roxb. is reported.


K A Suri* , N K Satti, B D Gupta & O P Suri









New flavonoid glycosides from Cassia occidentalis

From ethanolic extract of whole plant of Cassia accidentalis, 3,2˘-dihydroxy-7,8,4˘-trimethoxy­flavvone-5 O-{-b-d-glucopyranosyl(1→2)}-b-d-galacto­pyrano­side 1 and apigenin-7-O-b-d-allopy-ranoside 2 have been isolated. The structures have been established on the basis of chemical evidences and spectroscopic

1   R1 = R5 = OH,   R3 = R6 = CH3,   R4 = OCH3

   R2 = d-glucose-d-galactose sugar

2   R1 = R2 = R4 = R5 = R6 = H,   R3 = d-allose sugar


Chhavi Purwar*, Renu Rai,
Nidhi Srivastava & J Singh













Isolation and characterization of pectic polysaccharides from the fruits of Naringi crenulata

From the fruits of Naringi crenulata, the title polysaccharides have been isolated and their structures determined by various chemical and physical methods of analysis.






R=Galactan and/or arabinan or arabinogalactan side-chains




Saro Mondal, Bimalendu Ray*,
Swapnadip Thakur & Pradyot K Ghosal








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