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Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry




APRIL 2004



Advances in Contemporary Research



Applications of trivalent and pentavalent tantalum in organic synthesis

IPC: Int.Cl.7 C 01 G 35/00

Tantalum chloride is a versatile reagent/catalyst in organic synthesis and has been studied in new C-C bond formation reactions, as well as an efficient Lewis acid in Diels-Alder reaction, protection-deprotection mani­pu­la­tions and Sakurai reaction. This review covers the literature pertaining to tantalum halide published in the last decade.


Srivari Chandrasekhar*, Tokala Ramachandar &Tokala Shyamsunder




Synthesis of new ortho fused tetracyclic-2-substituted-4H-thiazolo[5,4-c]naphtho[1,2-e] pyran and its derivatives

IPC: Int.Cl.7 C 07 D 311/92

A facile synthesis of new ortho fused 2-substituted-4H-thiazolo [5,4-c]naphtho[1,2-e]pyrans 4a-p is described. These potentially bio-active molecules with slight non-planar geometry also exhibit interesting 1H NMR behaviour.



A M Kulkarni, N J Malviya & A V Karnik*



Synthesis of 1,4-bis-(2,4-dimethoxyphenyl)-2,3-bis-(4-methoxybenzyl)butane-1,4-dione

IPC: Int.Cl.7 C 07 C 45/00

The synthesis of meso and racemic 1,4-bis-(2,4-dimethoxyphenyl)-2,3-bis-(4-methoxybenzyl)butane-1,4-dione, a brackenin like molecule from commercially available 2,4-dimethoxybenzaldehyde is described.



 B Balram*,  B Ram &  S Raghu Ram



Utility of Vilsmeier Haack reagent in the synthesis of 3-amino-12-chloro quino[3,2-e][1,3]diazocines

IPC: Int.Cl.7 C 07 D 255/00

Application of Vilsmeier condition on 4-hydroxy­quinaldines gives a potential intermediate 4-chloro-3-formyl-2-(2-hydroxy-ethene-1-yl)quinolines which is utilized to prepare quino[3,2-e][1,3]diazocines on treat­ment with guanidine nitrate.


1                                              2                                                           12



R Nandha Kumar, T Suresh, T Dhanabal & P S Mohan*









Polymer bound Pd(0) phosphine catalyst for homogeneous catalysis

IPC: Int.Cl.7 C 01 G 55/00

Facile synthesis of water-soluble polymer bound Pd(0) phosphine catalyst is described. This recyclable polymeric catalyst is soluble in aqueous or aqueous / organic media and has high activity in nucleophilic allylic substitution, Heck reaction and hydrogenation



Nirmal Koshti*, Shubhangi Naik & Bharat Parab



Microwave assisted synthesis of a-(5-substituted-2-hydroxyaryl)-N-aryl nitrones and their NMR and mass spectral studies

IPC: Int.Cl.7 C 07 C 205/4

This article describes the microwave assisted synthesis of several new a-(5-substituted-2-hydroxyaryl)-N-aryl nitrones. The synthesized compounds are fully characterized by their one dimensional and two dimensional NMR spectra. The interesting features of their mass spectra are discussed.


2                           3                                                       4


V Sridharan , S Muthusubramanian* & S  Sivasubramanian









Synthesis and insecticidal activity of some 1,3,4-oxadiazoles derived from 2-chloro­pyridine-5-acetic acid

IPC: Int.Cl.7 C 07 D 271/10
// A 01 N 43/72

The synthesis of a number of 1,3,4-oxadiazoles molecules containing 2-chloro-5-methylpyridine moieties is described.



B Shivarama Holla*,C S Prasanna, Boja Poojary, K S Rao, K Shridhara & U Ganesha Bhat



Screening of natural products for new leads as inhibitors of IkBa kinase: Coumarin derivatives from plant extracts

IPC: Int.Cl.7 C 07 D 311/10

Mammea  A/AB 1, mammea A/AD 2,  1˘˘˘-acetoxy-mammea E/BB  3  and  mammea A/BB 4 have been  isolated by  bioactive  purification.  All the four compounds 1, 2, 3 and 4 are found to exhibit IkBa kinase inhibitory activity with an IC50 of  37.50, 23.50, 38.00 and 55.50 mM respectively.



N V S Ramakrishna*, A S Kulkarni, T S More, R G Bhat, S Krishnamurthy E P DeSouza, E K S Vijayakumar, R D Gupte & R V S V Vadlamudi





A new method for the synthesis of ethyl (1α, 5α, 6α)-3-benzyl-3-azabicyclo[3.1.0]hexane-2,4-dione-6-carboxylate: An intermediate for the trovafloxacin side chain

IPC: Int.Cl.7 C 07 D 221/00

A convenient and high yield process for of ethyl (1α,5α,6α)-3-benzyl-3-azabicyclo [3.1.0]hexane-2,4-dione-6-carboxylate using a facile endo-exo conversion by DBU is described.



K C Agrawal, Stuti Srivastava, Vishnu S Singh & Dinesh K Dikshit*, Prosenjit Bose, Pankaj Sharma & Naresh Kumar






Spiro-bithiazole derivatives of amidino­thiocarbamides: Novel utilization of the synthon 2- arylimino-5-carbethoxy-thiazolidin-4-one

IPC: Int.Cl.7 C 07 D 417/02

Amidinothiocarbamide and 3-arylamidinothio-carba­mides have been utilized in the synthesis of novel spiro-bithiazoles containing the amidino moiety by interaction with 2-arylimino-5-bromo-5-carbethoxy-thiazolidin-4-ones.



Madhukar S Chande* & Peter V R Carvalho



1,3-Dipolar cycloadditions: Part VIII ľ
Microwave irradiation assisted synthesis of N-methyl-C-arylnitrones

IPC: Int.Cl.7 C 07 C 205/00, 47/00

N-Methyl-C-arylnitrones have been synthesised in very high yields within a few minutes from N-methyl-hydroxylamine hydrochloride and aryl aldehydes in the presence of sodium hydrogen carbonate in methylene chloride using the microwave irradiation technique.



Avijit Banerji*, Pizush Kanti Biswas, Piyali Sengupta, Saugandha Dasgupta & Maya Gupta



A convenient procedure for the synthesis of phthalimides under microwave irradiation

IPC: Int.Cl.7 C 07 D 209/48

A rapid and efficient method for conversion of phthalic anhydrides 1 to phthalimides 2 and 3 under microwave irradiation is reported.



K Mogilaiah* & G Randheer Reddy



A simple and convenient synthesis of 4,6-disubstituted 3-cyanopyridin-2(1H)-ones under solvent-free microwave conditions

IPC: Int.Cl.7 C 07 D 213/00

A rapid and efficient method for the preparation of 4,6-disubstituted 3-cyanopyridin-2(1H)-ones 2 by the reaction between 1,3-diarylpropen-1-ones 1 and cyano­acetamide using powdered potassium hydroxide under microwave irradiation is reported.



1                                                                                                               2



Chaitanya G Dave, Dhaval A Shah & Yadvendra K Agrawal*



Efficient chemoselective liquid phase acylation of amines, alcohols and bifunctional compounds over ZSM-35

IPC: Int.Cl.7 C 01 B 39/00



R Srivastava & N Venkatathri*

ZSM-35, a medium pore zeolite, has been synthesized using ethylene diamine as organic template. The catalyst is used in the acylation of different amines, alcohols and bifunctional compounds. This material is found to be active and selective acid catalyst, exhibits not only very good activity but also very high chemo-selectivity towards monoacylation of bifunctional compounds. This material is more reactive for smaller organic compounds because of its pore dimension.   In case of bifunctional compounds like amino alcohols, amines are selectively acylated at lower temperature.


Acetylation of alcohols, phenols, thiols and amines catalysed by H-beta zeolite

IPC: Int.Cl.7 C 01 B 39/00





Pallooru Muni Bhaskar & Duraikkannu Loganathan*



Selective halogenation of 1-(2-hydroxy­phenyl)-3-phenylpropane-1, 3-diones using phase transfer catalysis and synthesis of 3-chloro- and 3-bromo-flavones

IPC: Int.Cl.7 C 07 D 311/02

Selective chlorination and bromination of 1-(2-hydroxyphenyl)-3-phenylpropane-1,3-diones have been achieved by their reaction with ammonium chloride/ammonium bromide and hydrogen peroxide in biphase medium using phase transfer catalysis.




J K Makrandi*, Shashi & Surender Kumar



Synthesis and biological activity of esters of 2-methyl-1,8-naphthyridine-3-carbamic acid

IPC: Int.Cl.7 C 07 C 269/04

// A 61 P 31/04, 31/10

2-Methyl-1,8-naphthyridine-3 carbazide 3, obtained from ethyl 2-methyl-1,8-naphthyridine-3-carboxylate 1, on heating with alcohols afforded 2-methyl-1,8-naphthyridine-3-carbamates 5.  They have been screened for their antimicrobial activity.




D Ramesh & B Sreenivasulu*



Synthesis and molluscicidal activity of (2-substituted)-spiro(cyclohexane)-1,5-[1,3,4] oxa/thiadiazolo[3,2-c] thiazolines

IPC: Int.Cl.7 C 07 D 271/10, 285/12

(2-Substituted)-spiro(cyclohexane)-1˘,5-[1,3,4]oxadia­zolo­­thia­­diazolo[3,2-c] thiazolines 3 and 6 have been synthesised.




Nizamuddin* & A Singh



Synthesis and microbiological activities of some pyrazolines and cyanopyridines

IPC: Int.Cl.7 C 07 D 245/00
// A 61 P 31/04, 31/10

A series of novel 1-H-3-aryl-5-(4˘-cinnamoyloxyphenyl)- pyrazolines 3, 2-amino-3-cyano-4-(4˘-cinnamoyloxy­phenyl)-6-aryl-pyridines 4, have been synthesized and evaluated for microbiological activities.




Sohit Rajvaidya, Jaladhi Vasavada & H H Parekh*



Synthesis and biological evaluation of pyrido-[1,2-a] pyrimidine and isoxazoline derivatives

IPC: Int.Cl.7 C 07 D 239/00
// A 61 P 31/04, 31/10