Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry;

Total visitors: 2,910  since 11-12-09

Special Issue on Interplay of Chemical and Biological Sciences: Impact on Health and Environment

VOL. 48B


December 2009







Adventures in heterocycle chemistry: The oxa-Michael cascade for the synthesis of complex natural products and highly functionalized bioactive compounds






N Volz, M C Bröhmer, J Toräng, M Nieger & S Bräse*


Institut für Organische Chemie, Karlsruhe Institute of Technology, Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany









Polymerization of 1,6-diynes — Scope, structure, and optical properties

A minireview is provided on recent advances in the field of 1,6-diyne polymerizations by olefin metathesis catalysts as well as the synthesis and characterization of related short-length oligoenes.














Constantin Czekelius*


Institut für Chemie und Biochemie, Freie Universität Berlin, Germany















Expanding the applications of locked nucleic acids


LNA nucleoside 5-triphosphates have been investigated as substrates for various DNA and RNA polymerases by performing primer extension reactions, PCR amplification and in vitro transcription reactions.













Rakesh N Veedu* & Jesper Wengel


Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55,

Odense M, 5230, Denmark










Synthesis and regioselective deacylation studies on peracylated 2′-azido arabino- and ribo-thymine nucleosides: Towards 5′-O,2′-N-linked oligo­nucleotides

Peracylated 1-(2′-azido-α-l-arabino-/β-d-ribofuranosyl)­thy­mine has been chemoenzymatically synthesized and subjected to deacylation studies in the presence of CAL-B (Candida antarctica lipase-B immobilized on polyacrylate) in aceto­nitrile.








Deepti Sharma, Anuj Khandelwal, Raman K Sharma, Sumati Bhatia, L Chandrashekar Reddy,
Carl E Olsen, Jesper Wengel, Virinder S Parmar & Ashok K Prasad*


Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India















Novel oligonucleotide analogues based on morpho­lino nucleoside subunits–Antisense technologies: New chemical possibilities












Tatyana V Abramova*, Marat F Kassakin & Vladimir N Silnikov


Instit′ute of Chemical Biology and Fundamental Medicine, Lavrent’ev Ave, 8, 630090, Novosibirsk, Russia









Lipase-catalyzed regio- and stereoselective de­acylation: Separation of anomers of peracylated a,b-d-ribofuranosides


Lipozyme® TL IM catalyzed regio- and stereoselective deacylation of the acyloxy function involving C-5-OH of the a-anomer over the other acyloxy function  in the anomeric mixture of peracylated a,b-d-ribofuranosides has been achieved. The enzymatic methodology finds application for the easy and efficient separation of acylates of anomers of a,b-d-ribofuranosides.















Raman K Sharma, Neha Aggarwal, Anu Arya, Carl E Olsen, Virinder S Parmar & Ashok K Prasad*


Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India















Synthesis and antimicrobial activity of 5-(2-aminothiazol-4-yl)-3, 4-dihydro-4-phenyl pyrimi­din-2(1H)-one


An efficient cyclocondensation of appropriately substituted of 2 with thiourea in ethanol proceeds in high yield to furnish the corresponding substituted 5-(2-aminothiazol-4-yl)-3, 4-dihydro-4-phenyl pyrimidin-2(1H)-one.





Kushal R Lanjewar, Anjali M Rahatgaonkar, Mukund S Chorghade* & Binda D Saraf


Chemistry Department, Institute of Science, R T M Nagpur University, Nagpur 440 001, India









Synthesis and lipase-catalysed enantioselective acylation studies on ethyl 4-aryl-3,4-dihydropyri­midin-2(1H)-ones


A series of different analogs of 4-aryl-3,4-dihydropyrimidin-2(1H)-one have been synthesized and their biocatalytic resolution has been carried out using immobilized lipase CAL-L(A) (immobilized on accurel).






Ashok K Prasad, Pragya Arya, Sumati Bhatia, Raman K Sharma, Rishipal Singh, Brajendra K Singh,
Erik Van der Eycken, Rajpal Singh, Carl E Olsen & Virinder S Parmar


Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India









Weinreb amide based building blocks for convenient access to various synthetic targets

New building blocks based on Weinreb-amide functionality for the synthesis of various important targets are described.








B Sivaraman, B N Manjunath, A Senthilmurugan, K Harikrishna & Aidhen Indrapal Singh*


Department of Chemistry, Indian Institute of Technology, Madras, Chennai 600 036, India












Synthesis of new succinate-dihydrotestosterone-dihydropyrimidine conjugate





L Figueroa-Valverde*, F Díaz-Cedillo & A Camacho-Luis


Facultad de Ciencias Químico-Biológicas, Lab de Farmaco-química, Universidad Autónoma de Campeche,

Av. Agustín Melgar s/n entre calle Juan de la Barrera y C-20, Col Buenavista C.P.24039 Campeche Cam, México









Mammalian target of rapamycin (mTOR) inhibitors with therapeutic potential for colitis






Vijaykumar Deore, Mandar R Bhonde, Ram A Vishwakarma, Nilesh M Dagia, Sanjay Kumar &
Abhijit Roychowdhury


Department of Medicinal Chemistry & Department of Pharmacology, Piramal Life Sciences
1-Nirlon Complex, Off Western Express Highway, Goregaon (E), Mumbai 400 063, India









Synthesis of nano-sized C3-symmetric 2,4,6-triphenyl-1,3,5-s-triazine and 1,3,5-triphenylben­zene derivatives via the trimerization followed by Suzuki-Miyaura cross-coupling or O-alkylation reactions and their biological evaluation


C3-symmetric biphenyl-based and triphenoxy derivatives of 1,3,5-s-traizine and 1,3,5-triphenyl benzene have been synthesized using a sequence of cyclotrimerization and Suzuki-Miyaura cross-coupling or O-alkylation reactions and the biological activity of O-alkylated triazines has been tested towards HeLa cell proliferation.





Sambasivarao Kotha*, Dhurke Kashinath, Manu Lopus & Dulal Panda

Department of Chemistry, Indian Institute of Technology-Bombay, Powai, Mumbai 400 076, India












Green methodologies in synthesis and natural product chemistry of phenolic compounds





Arun K Sinha*, Naina Sharma, Amit Shard, Abhishek Sharma, Rakesh Kumar & Upendra K Sharma


Natural Plant Products Division, Institute of Himalayan Bioresource, Technology, Palampur 176 061, India









Experimental and computational evaluation of new quinolinyl chalcones as potent antiplasmodial agents

In a search for new antiplasmodial agents against Plasmodium falciparum, a series of thirty five diversely substituted chalcones derived from a quinoline scaffold e.g. (E)-3-(2-chloroquinolin-3-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one/(E)-(2-chloro-6-ethoxyquinolin-3-yl)(2-hydroxyphenyl) prop-2-en-1-one and (2Z)-3-(2-chloroquinolin-3-yl)-1-(2-hydroxy­henyl)-3-iodoprop-2-en-1-one are prepared and studied for their binding in the active sites of Plasmodium falciparum lactate dehydrogenase (pfLDH) enzyme.




2a-j                                                                                             3a-j




Shikha S Dave, Ajay M Ghatole, Anjali M Rahatgaonkar, Mukund S Chorghade*,

P M S Chauhan & Kumkum Srivastava


Chemistry Department, Institute of Science, Civil Lines, Nagpur 440 001, India














Synthesis and studies on antimicrobial, anti­inflammatory and antiproliferative activities of  heterocycles derived from 4-/5-/6-/7-nitro/5-fluoro/chloro/bromoindole-2-carbohydrazides


Synthesis and studies on antimicrobial, antiinflammatory and anti­proliferative activities of heterocycles derived from 4-/5-/6-/7-nitro/5-fluoro/chloro/bromoindole-2-carbohydrazides are reported.




B Narayana, B  V Ashalatha, K K Vijaya Raj & B K Sarojini


Department of  Studies and Research in Chemistry, Mangalore University, Mangalagangotri  574 199, India









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