Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry;

Total visitors: 2,846  since 10-11-09

VOL. 48B


November 2009


Rapid Communication





Novel fluorescence emissions from 3-styrylindoles

Fluorescence emission features of 1-5 in solution and solid-state are described.





Anil K Singh* & Abera Asefa


Department of Chemistry, Indian Institute of Technology Bombay Powai, Mumbai 400 076, India















Synthesis and biological activities of new 7-o-b-d-glucopyranosyloxy-3-(3-oxo-3-arylprop-1-enyl)-chromones

A convenient route to synthesize some new medicinally important 7-hydroxy-3-(3-oxo-3-arylprop-1-enyl)-chromones and their o-b-d-glucosides is described.




K M Hatzade, V S Taile, P K Gaidhane, V D Umare, A G M Haldar & V N Ingle*


Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur 440 033, India














Synthesis and antimicrobial screening of 4H-2-acetyl-3-acetyamido furo[3,2-c] benzopyran 4-one, 11H-2,4-dimethyl-3,4-dihydro-3-amino-4-hy­dro­xy-pyrimido [3,2-d]furo [3,2-c] benzopyran-11-one and 4H-2-acetyl-3-(3-methyl-1,2,4-tria­zol-4-yl) furo[3,2-c] benzopyran 4-one






V V Mulwad* & A S Hegde

Department of Chemistry, The Institute of Science, 15, Madam Cama Road, Mumbai 400 032, India









Spectral and single crystal X-ray structure of 4-(4′-methyl) benzylidene amino-5-phenyl-3-merca­pto-1,2,4-triazole and its antimicrobial activity


4-(4-Methyl) benzylidene amino-5-phenyl-3-mercapto-1,2,4-triazole (MBPMT) has been synthesized and characterized by spectroscopic analysis and single crystal X-ray diffraction pattern. The antimicrobial activity of MBPMT in DMSO medium is also assessed.





Aliya Begum, A V Aparna, B Sireesha, Ch Sarala Devi* & Pallepogu Raghavaiah


Department of Chemistry, Nizam College, Osmania University, Basheerbagh, Hyderabad 500 001, India








Evaluation of lipophilicity, antimicrobial activity and mutagenicity of some novel ester prodrugs of metronidazole


Various novel aliphatic and aromatic prodrug derivatives of MTZ have been synthesized and reported for their lipophilicity, anaerobic antimicrobial activity and mutagenicity using Ames mutagenicity assay.




Sonal Dubey*, Vinod Jain & G B  Preethi

K.L.E.S’s College of Pharmacy, Rajajinagar, Bangalore  560 010, India














Synthesis of biologically active benzothiazole substi­tuted thiazolidinone derivatives via cycliza­tion of unsymmetrical imines




Arasampattu S Nagarajan, S Kamalraj*, J Muthumary & Boreddy S R Reddy

Industrial Chemistry Laboratory, Central Leather Research Institute, Chennai 600 020, India









Synthesis of phthalimido or succinimido-[2-aryl-4-oxo-3-[{2-oxo-2-(phenothiazin-10-yl)ethyl}­ami­no]-1,3-thiazolidin-5-yl]ethanoate and their anti­microbial activities


Some phthalimido or succinimido-[2-aryl-4-oxo-3-[{2-oxo-2-(phenothiazin-10-yl) ethyl}amino]-1,3-thiazolidin-5-yl]ethano­ates 6a-h have been synthesized by (chloroacetyl)­phenol­thia­zine 1 through multiple step approach. Synthesized compounds are characterized by analytical and spectral studies and evaluated for antimicrobial activities.



Vijay Kumar Salvi, Shweta Sharma, Chirag Sharma, Dinesh Bhambi & G L Talesara*


Synthetic Organic Chemistry Laboratory, Department of Chemistry, M L Sukhadia University, Udaipur 313 001, India















Synthesis of quinoxaline quinones and regio­selectivity in their Diels-Alder cycloadditions












Gitanjali Sharma, Pankaj Raisinghani, Ignatious Abraham, R T Pardasani* & Tulsi Mukherjee

Department of Chemistry, University of Rajasthan, Jaipur 302 055, India
















Study on characterization and degree of esterification of styrene maleic anhydride by some medicines


Poly(styrene-co-maleic anhydride) conjugates with phenol based medicinal natural products like 2-methoxy-4-(2-propenyl)-phenol etc. in acetone and dioxane. The hydrolytic and binding behavior of the phenol based medicine was compared with the degree of esterification.











Ravish Singh Rajput*, D C Rupainwar, Rama Kant Singh & Amarika Singh


Applied Chemistry Division, Institute of Engineering and Technology, Sitapur Road, Lucknow 226 021, India















Microwave and conventional techniques for the synthesis of a series of pyrazolo [5,4-d]­pyri­midine derivatives and their antimicrobial screening


1-{4′-[(4′′-6′′-diaryl-(1′′,3′′,5′′-triazin-2′′-yl)) amino]phenyl}-3-methyl-4-(substituted phenyl)-4,5-dihydcrobialropyrazolo[5,4-d]pyrimidin-6-ol 4I-XXX and 1-{4′-[(4′′-6′′-diaryl-(1′′,3′′,5′′-triazin-2′′-yl)) amino] phenyl}-3-methyl-4-(substitutedphenyl)-4,5-dihydro pyrazolo[5,4-d]pyrimidin-6-thiol 5I-XXX have been synthesized from 1-{4′-[(4′′,6′′-diaryl-(1′′,3′′,5′′-triazin-2′′-yl))amino]phenyl}-3-methyl-2-pyrazolin-5-one 3. Both the reactions have been carried out by conventional and microwave methods. All the synthesized compounds 4I-XXX and 5I-XXX have been tested for their antimicrobial activity and the structures of the synthesized compounds have been established on the basis of elemental analysis and spectral data.
















P B Rana, J A Patel, B D Mistry* & K R Desai


Department of Chemistry, B.K.M Science College, Valsad 396 001, India















Novel pyrazolopyrones from enol lactones


Isomeric pyrazolopyrones 6-9 have been synthesized from one pot and facile condensation of chloroformylpyrazole 1, azidoformylpyrazole 2 with enol lactones 3 and 4 in good yield. The newly synthesized compounds have been characterized by IR, 1H NMR and mass spectral data.





Zeba N Siddiqui* & Mohammad Asad


Department of Chemistry, Aligarh Muslim University, Aligarh 202 002, India









Microwave assisted synthesis and antimicrobial activity of some 2-(benzofuran-2-yl)-7-(substi­tu­ted)imidazo[2,1-b]benzothiazoles


2-(Benzofuran-2-yl)-7-(substituted) imidazo[2,1-b]benzothia­zo­les have been prepared by condensation of 2-(2-bromo­acetyl)benzofurans and various 2-amino-7-(substituted) benzo­thiazoles under normal thermal condition as well as microwave irradiation. The latter condition for the reaction has been found to be much more efficient in terms of the time and yield. The structures of the compounds 1a-l have been established on the basis of their elemental analysis, IR and 1H NMR spectral data. The antibacterial and antifungal properties of these compounds are described.





Rekha Rani & J K Makrandi*


Department of Chemistry, Maharshi Dayanand University, Rohtak 124 001, India






Authors for correspondence are indicated by (*)